Getting an ergonomic mouse has really helped me with reducing the pain from my carpal tunnel. I don't know how much of a difference it would make in preventing it altogether, but I imagine that it would help. It looks stupid and it takes some time to get used to it, but once you do, it works well enough. Personally I haven't noticed any difference in performance compared to a regular mouse, but then I already suck at pvp, so maybe it's just a case of "can't get any worse"...