I wouldn't say it's tiring. I do find it a bit bassy, punchy, which I like. Headphones/iems that make me "tired" is those that has piercing trebles, which I don't find in the M50x. But I'm not that comfortable using my M50x anymore lately, especially for home use because I'm too used to open backs, the closed back and tuning of the M50x make me a bit claustrophobic, somehow. As for details in the sound, it does have a good instrument separation. Sometimes it can be exhausting listening to many things at once I agree, but I'm already used to it I guess.