The Romans retaliated with excursions well into the third century CE. There is a battlefield in lower Saxony that is dated to 235 CE, the Harzhorn battle. There is a museum there now with a very detailed description of this site, which seems to have been a major battle, not just a skirmish, between Romans and Germanic tribes. But the Roman empire at this point did not to have the resources to occupy and romanize Germania east of the Rhine.

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sources: https://roemerschlachtamharzhorn.de/