Christian Bale in Vice? Colin Farrell in The Batman? Tom Cruise in Tropic Thunder? Charlize Theron in Monster? Nicole Kidman in Destroyer? Charlize Theron and Nicole Kidman in Bombshell? Doug Bradley in Hellraiser? Brendan Frasier in The Whale? John Travolta in Hairspray? Robin Williams in Mrs Doubtfire? Dustin Hoffman in Tootsie?

That's just off the top of my head. There's lots of examples.