OK, I travel for work and live in Nashua. Nashua is ~45 minutes from Logan almost always, unless you have to get to or from there in the heart of rush hour. Manchester airport is a UPS hub more than a passenger airport, it has only a few direct flights and as such never has directs to where I need to go (major cities in the US, Europe and Asia).

Nashua is a great place for food, provides easy access to the entire region and will provide an easy reverse commute for your wife's job. Most neighborhoods are great, just avoid living right downtown, south of the Nashua River, and you're fine. Happy to provide more insight, if you want details.

Southern NH has some Real Estate availability issues due to the now-waning covid housing boom, but prices are sliding slowly now.