Favorite is Route 29 from Trenton to Frenchtown.

(The PA side is better though and I would argue one of the nicest drives in the East), basically it hugs the river more than 29 does.

Worst - I second Route 22 in Union. I still want to see a movie with an evil villain who then forces his nemesis to walk across it at rush hour, and seeing the protagonist as scared as if they were walking the plank.