Call AMVETS and they will come to your house and pick up bags or boxes right off your front porch, you don't even need to be home. They will sort and sell the items at a "Red White and Blue thrift store and use the profits for helping out veterans.

A lot of schools have big donation bins outside of them that you can drop off at. The companies that take the clothes will pay the school, or organization identified on the bin a small amount of money based on the weight of the items in the bin. I know schools that have them to raise funds for the marching band, performing arts, and some sports boosters. Unfortunately, some of those bins fill up and nobody comes around to pick up so stuff sits out, which it shouldn't, or you cannot donate until it gets emptied.

Good Will is OK, but it isn't all that charitable. They use money from their sales to pay their employees and train them to get jobs in other retail stores. A lot of their profits go to the founder/ CEO and executives' salaries, while the store workers make minimal salaries. So they get a bit less of my donations, but they still get some because I can drop off pretty much any time I want.