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EconomistPunter t1_j9vj0ib wrote

Again, early studies on this suffered from data limitations. We don’t really know much. This research sphere is filled with dubious claims.

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PEVEI t1_j9vjvfy wrote

I agree, and this unreviewed study with a modest sample analyzed with MR is one of those.

Having said that there have been some longitudinal studies on the harm of smoking marijuana, which is generally argued to be the most harmful way to take it, they've proven unable to find even a corollary.

There have been a few which find a very slight signal of possible lung cancer risk in heavy marijuana smokers after a 40 year follow-up, but it's tenuous.

Still others have looked at links between coronary vessel disease and marijuana, with the benefit of peer review and publication. They found nothing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343712

Some studies attempted to find a link between marijuana use and stroke or myocardial infarction, but they inevitably fall apart when confounding factors such as smoking, drinking, and other high risk behaviors are accounted for.

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EconomistPunter t1_j9vkov0 wrote

And some of the early marijuana laws specifically targeted a substitution relationship between opioids and marijuana, which have largely evaporated in more recent studies. That’s certainly harm understatement.

Marijuana research suffers from both attenuation bias and bias that increases the magnitude of results. It’s a glorious mess in the sphere.

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