Depends on where you're going from. If you're anywhere near the parade in midtown, find an underground way to Penn and take NJT to the airtrain station one stop beyond Newark, leave with plenty of time. Downtown or Brooklyn/Queens, I'd try to cross lower manhattan or Staten Island to stay clear of the parade. I need to be in Princeton by 1 from Astoria, my plan is Woodside LIRR to Penn, then NE Corridor to Princeton to avoid all the parade stuff that will be wrapping up then.