Some of my faves were already mentioned but I'll throw them up again: Human Robot, Triple Bottom Brewing, ARS, Love City

Just across the Delaware is Forgotten Boardwalk. They do some very creative brews with an amazing boardwalk-themed taproom; it's well-worth the visit. For non-breweries, Memphis Taproom is a special fave (go for brunch and get the kielbasa breakfast platter), and I love the Garden at Cherry Street Pier (mostly for the environment, but they serve a good number of local beers).

I'll also give some love to Philadelphia Brewing Company. Yes, they're not the best beers I've ever had (my spouse describes the Kenzinger as "what would be in a plain can just labeled 'Beer'"), but it's very spacious and just kind of a nice outdoor hang where you don't feel on top of anybody. Plus they get some great food trucks that come by. It's probably not worth a specific trip, but if you're in the neighborhood I'd at least drop by.