I fortunately don’t have to drive throughout the city often anymore, but I’d say that Chinatown is the most frustrating (trying to weave through parked trucks, drivers of said trucks unloading stuff and moving it across the street, double parked cars, people running out in front of you), the craziest is the Boulevard (particularly as you get up into the Northeast), and the worst is Lincoln Drive. granted I haven’t had to take Lincoln since before COVID but when I had to take it often, people treated it like their own personal F1 course and the potholes were atrocious