Could just be that groups of natural and unnatural systems can be seen as predictable while the whole picture is completely unknowable no matter how complex our knowledge of everything becomes. Even if you knew the start state of the universe, could you predict everything? I'd say not purely on the basis that micro and macro do end up meeting in (dare I say) completely unexpected ways. For eg, a bit flip in computing constitutes a binary digit being flipped by something as random as a perfectly timed cosmic ray hitting memory at the perfect moment in the right spot to cause a flip - rewind the universe and let it do its thing for the same amount of time and you MAY get that same flip but chances are, things will be very different purely based off early universe quantum effects. The same happens in biology and is an argument for different evolutionary steps. Maybe humans are the cause of a miraculous bit flip in the cosmic goo. We may not be special in the universe but the fact that we could be made a certain way based on random cosmic rays? 1 bit flip potentially happening on average every 30-something-ish hours to one bit in memory, extrapolated on a quantum yet universal level? I'd also have to say that I personally can see the argument for our own brains as analogous to quantum computing. If you accept certain ideas and some research, maybe brain patterns inherently recognise and interact with quantum entangled states. Is the chance of thought and the fact that it may be able to mediate and navigate these states as changes in thought patterns deterministic? Actually asking tbh...

Determinism always pisses me off, as I'm sure it does to it's arguers lol.