Are you suggesting all our inventions, which work, as far as we know, specifically because they were designed to work based upon our robust empirical knowledge of the physical reality upon which they work, are actually working by coincidence?

For example, genetic engineering doesn't work because our incredible, and entirely unfalsified library of empirical knowledge of chemistry and biology allows us to precisely manipulate genes to produce expected proteins, and expected results, but because by sheer coincidence all these observations happen to be entirely consistent with a completely different system, and all of our direct observations, include electron microscopy, are erroneous, while, again, being, by a coincidence in the order of quintillions to one, entirely consistent with actual reality?

Things we do not yet know about reality cannot negate what we do already know, and testably and consistently works. No matter what we learn about quantumn physics, time, space, etc, will stop chemistry from working the way we know it works. No discovery will magically change the structure or function of proteins, or the structures they form.