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dropkickpa t1_jdsx93c wrote

Reply to comment by Aggravating_Foot_528 in Animal sedative posing increased threat in local drug overdoses by Ready_Panda

Yohimbine and several other a2 antagonists reverse it, but not nearly as well as narcan does for opiates (no sudden reversal like narcan, it can take up to 20 minutes to take wake up an animal patient after administration, if it's not too late), and it's not something regularly kept in any med kit outside of vet med, and only there when xylazine is used (typically purchased when the xylazine is purchased, and never at any other point). Also, the safety margin for xylazine is REALLY small.

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Aggravating_Foot_528 t1_jdt1avg wrote

Omg. I haven't thought about yohembine since 2000 or so. I think that was used in human medicine for erectile dysfunction iirc.

I think the safety margin in humans is much greater given the large uncontrolled trial going on in Philly. I do think the sleeping for 24+ hours with it can be dangerous if you're exposed to the elements or not eating but it doesn't seem like it kills humans. And I'm assuming people are just shooting themselves up with massive doses.

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dropkickpa t1_jdt2zek wrote

It probably is safer for humans, i know with small animals a small error in calculations can be deadly pretty quickly.

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