Comments

You must log in or register to comment.

AutoModerator t1_j8gupi8 wrote

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

1

helloitsme1011 t1_j8guxtv wrote

Damn I guess save your liver at the cost of your kidneys :/

2

GamingCupcake t1_j8gwqij wrote

Per the linked article, high coffee consumption = “three or more cups of coffee each day”

211

despitegirls t1_j8h171t wrote

For those who like me read "cups" and thought that was an insufficient unit of measure given different brewing methods:

>The caffeine content per cup was defined as 100 mg of Italian espresso coffee, which was the most abundantly consumed type of coffee by the HARVEST participants. Decaffeinated coffee, tea, and other caffeinated drinks were not taken into account in the present study because they were rarely consumed in these areas of Italy.

8

Antumbra_Ferox t1_j8h4jjx wrote

I read the article so you lot wouldn't have to. It's about a gene that makes some people metabolise caffeine three times slower than others which can cause problems at high levels of caffeine consumption. Not about coffee being harmful to kidneys in and of itself.

Personal hypothesis: I imagine 3 cups a day with an ~18 hour half-life would mean their bodies never get a break.

116

user_173 t1_j8h66xh wrote

To live is to die. Nope, you won't take it from me, it's mine, my precious.

28

ImageComfortable2843 t1_j8harq0 wrote

I quit drinking all caffeine during the pandemic due to working at home and not really having to get ready every day. once I went back to getting up at 5 AM and driving to the office I realized I just didn’t need it anymore. I feel like a totally different person now. I got a Starbucks in the airport and felt like my head was going to explode and i used to drink 2-4 16oz cups a day for like 14 years.

7

Runecian t1_j8hfepk wrote

I am resigned to my caffeinated oblivion, thank you very much.

8

AshenAmarantos t1_j8hh6nc wrote

Annoyingly, this article does not say what alleles of rs762551 increase the metabolization of caffeine, so I had to look it up. C/A and C/C are the slower variants; there's apparently little difference between C/A and C/C metabolization according to SNPedia. A/A is ultrarapid metabolization. The article implies only A/A is good to go.

Useful if you had a DNA test and want to look up what you are--which I have and did immediately after reading this. Thankfully, I was A/A.

Sauce: https://www.snpedia.com/index.php/Rs762551

31

dcheesi t1_j8i73gq wrote

Replying to meontheinternetxx (#1,807,018)

Studies generally say yes, though the particulars may vary from study to study. Certainly regular drip coffee helps, and some studies indicate that other types of coffee may also be beneficial.

The caffeine itself seems to be part of it, although other sources such as tea have confounding factors (e.g. tannins) that may limit their benefit. Coffee seems to have the clearest evidence of a consistent benefit.

Decaf coffee, if you're wondering, has less evidence in favor of it. The conventional wisdom from previous studies suggested that it should be less effective; however, at least one recent study reported a similar benefit to regular coffee.

2

justwastingtimw t1_j8if9vv wrote

My poor kidneys don’t stand a chance. Tea Coffee.beer. No hope left

9

Exotic-Combination10 t1_j8ifupm wrote

Well, at least now I know exactly how I'm going to die sips on probably 6th cup today

6

halofreak7777 t1_j8iqwnm wrote

Replying to GamingCupcake (#1,804,683)

They never defined what kind of cup they are talking about. 8oz per cup? Or the same kind of "cup" as listed on my French press. Because my French press says it makes 8 "cups", but its only 32oz or 4 actual cups and I only drink 4 "cups", which is 2 actual 8oz servings.

2

Chardonneh t1_j8iukj2 wrote

In"some" people. My dad is 91 years old and only drinks coffee, but has admitted to downing pills with water. I've only seen him have the occasional beer on a hot day, and his go to social drink was gin with Wink (I wonder if they even sell Wink anymore).

1

pacwess t1_j8izuu4 wrote

Caffeine. So I assume any caffeinated beverage could be included?

3

HammerTim81 t1_j8jbnwv wrote

So Italy has higher prevalence of kidney disfunction?

2

WhiteChocolatey t1_j8jhobw wrote

Kidneys are overrated anyways. I was an alcoholic before switching entirely to caffeine addiction. I’m just gonna roll the dice on this one

1

SpecialistNo7265 t1_j8jn3o6 wrote

Conventionally grown coffee or pesticide-free coffee ? Or either could be just as harmful if you happen to have the wrong gene?

0

Jairlyn t1_j8jptqr wrote

You can have my coffee when you pry it from my cold dead kidney !

2

InVerum t1_j8jwc0z wrote

I have two double espressos a day... So definitely fall over this line.

Oh well!

1

Misabi t1_j8jwia7 wrote

Replying to keylimedragon (#1,810,354)

>The report says they're treating a cup as 100mg of caffeine from Italian espresso.

Traditionally that would also be made with coffee containing more robusta beans in Italy, which has higher caffeine than the Arabica coffee generally used in the US. A double shot of espresso made from arabica in most coffee shops would likely contain 60mg to 80mg of caffeine.

"Espresso typically has 63 mg of caffeine in 1 ounce (the amount in one shot), according to Department of Agriculture nutrition data. Regular coffee, by contrast, has 12 to 16 mg of caffeine in every ounce, on average. That means that ounce for ounce, espresso has more caffeine.6/01/2023"

source

1

keylimedragon t1_j8k2bfl wrote

Replying to Misabi (#1,811,130)

The study doesn't say, but I'm wondering if since it's an observational study, they estimated total mg of caffeine per day and divided by 100 to get cups. But it's weird that they specify Italian espresso specifically and you're right that an espresso shot has about 60-65mg so it would be about 1.5 shots per cup.

1

aristorat t1_j8k906z wrote

That's why I stick to monsters

1

UnluckyNate t1_j8keuks wrote

Replying to Jets237 (#1,811,114)

I work in healthcare and a patient let me know a life-hack for alcohol use that should also work for coffee. He said, if you never let your glass get empty, it only counts as one drink

8

thecwestions t1_j8ko5f8 wrote

I refuse to read this study. I only accept good news that supports my addictive tendencies. (Nervously sips red wine)

1

Fy_Faen t1_j8ktn32 wrote

Replying to HippieInDisguise2_0 (#1,811,948)

You should be concerned about the uses you haven't imagined, rather than the ones you already have. DNA is what makes you, YOU, and once that information is outside your control, there's nothing you can do to change it.

1

Iwillnotbeokay t1_j8kugx1 wrote

Dammit, can’t I just have one thing I like that isn’t gonna somehow kill/bankrupt/disfigure me??

1

Shootemout t1_j8nesqo wrote

Replying to HippieInDisguise2_0 (#1,811,948)

the only thing i would be concerned with is how insurance companies could interact with individuals that have a hereditary disease (a.k.a denial of coverage due to a 'pre-existing conditon'). It's illegal for them to deny you *now* but in 5, 10 or even 15 years it could change.

3