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nickyfrags69 t1_j8x8ysr wrote

>but compounds that primarily modulate the serotonin system do relieve it

That's not necessarily accurate though. First off, Ketamine has a much higher success rate, suggesting at the bare minimum that other mechanisms can relieve depression without touching serotonin receptors. Second, most of the benefit of SSRIs seem to be indirect/downstream, which is why they take so long to kick in.

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