letmeinmannnnn t1_j98ff8v wrote on February 20, 2023 at 1:19 AM

Reply to comment by basmwklz in Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model (2023) by basmwklz

So high LDL helped? Or made it worse?

Tagthedog t1_j992kei wrote on February 20, 2023 at 4:36 AM

Helped, High LDL reduced IL-10 which enabled more CD4+T cells to differentiate into central memory-like phenotype - which is essential for prolonged anti-tumor immunity and durable response to checkpoint blockade.

There is a positive correlation between obesity and response to checkpoint blockade, this may be fishing out the reason why.

letmeinmannnnn t1_j994euc wrote on February 20, 2023 at 4:54 AM

Interesting, I've also read those with elevated LP(a) tend to have less cancer occurrence, maybe it's linked, I'll try find more info

Tagthedog t1_j9arcay wrote on February 20, 2023 at 3:42 PM

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789456

In case you were interested