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patacakeq t1_je5vtm3 wrote

As someone with MS I am really hopeful and interested to see where this research goes.

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8Bells t1_je62j8i wrote

This is pretty interesting. I wonder if this will foster any trials regarding fecal transplants for MS. Or what a potential fix for reducing the epsilon toxins production rate could be.

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TreeHawkFeather t1_je6txe4 wrote

And the studies linking gut bacteria to anxiety/panic-disorder too. So much to learn about gut bacteria.

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Bardhyll t1_je7fdtd wrote

Replying to give_me_yr_coffee (#2,460,920)

I’ve personally seen surprising improvement using the opposite approach - the addition of a low grade antibiotic (doxycycline) course. It’s been the only change to her treatment in the last several years. It’s astounding to see someone with relapsing remitting MS go from barely able to lift her hand to feed herself to almost standing on her own and doing a couple laps around the living room with a walker.

Edit: to add this is obviously an n of 1 anecdote, but it gives me an insight to investigate further.

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mrlolloran t1_je7paxi wrote

In mice.

This study was done on mice. I have MS, stop omitting this, it gives people suffering from the disease false hope.

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AM_OR_FA_TI t1_je84qw8 wrote

Replying to gertalives (#2,469,354)

Well yeah that’s true but if it prevents growth on improperly chilled meats for 6, 12 hours etc. then it stands to reason the bacteria still doesn’t like them in the small intestine either. I don’t see how it’s likely to change?

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Bardhyll t1_je87jsc wrote

Replying to give_me_yr_coffee (#2,466,181)

With a disease like MS very little is known definitively about the direct cause. The broad theory is that something triggers the immune system to attack the nerve cells causing severe scaring (sclerosis) which degrades or eventually completely blocks neuron function. The biggest puzzle has been what causes the blood brain barrier breach in this autoimmune reaction. However, given how much we are now uncovering regarding the gut microbiome link with brain function and mental health, it’s plausible that a Clostridium infection in the gut could open such a pathway.

After posting my comment above I went back to the literature and confirmed that doxycycline does indeed cover clostridium perfringens. I would be very interested to see a patient trial, but I don’t expect many pharmaceutical companies are lining up to discover a new disease treatment for a drug that has been in commercial use for more than 50 years.

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AM_OR_FA_TI t1_je88ewe wrote

Replying to Meajaq (#2,470,952)

But if you put these things into gelatin capsules, the same kind designed for OTC herbal supplements, they’re formulated to dissolve within the small intestine, which is where this particular bacteria and toxin are being produced. I’m not suggesting it totally ameliorates it, but I think it strongly stands to reason that it’d likely reduce numbers or severity some.

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psychoskaggot t1_je8k74v wrote

Replying to TreeHawkFeather (#2,460,589)

Since ancient china physicians have linked the guy to feelings of stress and anxiety, the liver to angst and anger, the lungs to worry, the heart to sadness etc. Your emotions and your body communicate to you about the same issues sometimes

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