Submitted by MistWeaver80 t3_124chph in science
One thought here, it’s my understanding that some of the medications for these increase the risks. I grew up with pretty bad asthma and had to take prednisone for a while and I know I was told prednisone can increase this risk. I don’t know if prednisone specifically is prescribed for eczema but I wouldn’t be surprised if something similar was since both are autoimmune.
So I’m wondering if it’s due to medications that are used for these conditions that’s causing this
Oral prednisone can cause osteonecrosis and chindroblast suppression if given long term. Like you said we tend to only prescribe it in severe asthma (stage 5) or in very short courses with eczema. Inhaled (given in asthma) and topical (skin conditions) don’t have this side effect. If the study’s findings are accurate there is most likely another factor(s) causing this, but no doubt the small population of asthmatics taking orals long term aren’t helping this statistic. At the end of the day though, joint pain > dying from hypoxemia. Ez trade
Eczema and asthma are both autoimmune diseases. It suggests that either osteoarthritis is an autoimmune disease (like rheumatoid arthritis) or that immune suppressing drugs cause it.
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Copious amounts of prednisone and or stimulants. It's not good for the body...
Great, so I got that look forward to
> ⇒ This study demonstrates an association between atopic disease and the development of OA; patients may benefit from the use of treatments that inhibit mast cells and allergic cytokines to treat or prevent OA.
Ketotifen fumarate (Zaditen®; Swedish Orphan Biovitrum) functions as a mast cell stabiliser and has been used as a treatment for chronic idiopathic urticaria because of its antipruritic properties. Similarly, epinastine hydrochloride is both an antihistamine and a mast cell stabiliser.
Within the flavone class, the most active mast cell stabilizers are luteolin, disometin and apigenin. Using anti-IgE to elicit degranulation, luteolin inhibited the release of histamine, LTs, PG2 and GM-CSF from human cultured mast cells (HCMCs) in a concentration-dependent manner (1–100 μM) (Kimata et al., 2000b). Luteolin also suppressed the production of proinflammatory cytokines TNF-α and IL-6 in bone marrow-derived cultured murine mast cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764846/
Glucosamine stabilizes mast cells as well.
42% higher after adjusting for bmi. Still very high and significant but makes more sense to use the bmi adjusted number.
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It's hard for me to understand the importance of this correlation - it seems like having any chronic illness makes you more likely to have nearly any other chronic illness.
They are all inflammatory / auto immune diseases. That's the link.
Heeeey, have chronic, acute asthma for 37yrs now, have had osteoarthritis in my lumbar, and now I'm being screened for RA. ISNT THIS FUN!?
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N = 100,000+ is impressive sample size. Don't see that very often
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I'm not a person in the medical field, so I have no clue how close or far off this question may be. Could it be lack of oxygen and water causing osteoarthritis? Since people with asthma will have a harder time getting oxygen and others with eczema might not hydrate enough.
tklite t1_jdywzmw wrote
Eczema and asthma are inflammatory conditions, pointing that the development of osteoarthritis is also an inflammatory condition. Poorly controlled eczema and asthma that over relies on the use of oral steroids can also lead to osteoarthritis.