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tklite t1_jdywzmw wrote

Eczema and asthma are inflammatory conditions, pointing that the development of osteoarthritis is also an inflammatory condition. Poorly controlled eczema and asthma that over relies on the use of oral steroids can also lead to osteoarthritis.


theblackd t1_jdyy2vh wrote

One thought here, it’s my understanding that some of the medications for these increase the risks. I grew up with pretty bad asthma and had to take prednisone for a while and I know I was told prednisone can increase this risk. I don’t know if prednisone specifically is prescribed for eczema but I wouldn’t be surprised if something similar was since both are autoimmune.

So I’m wondering if it’s due to medications that are used for these conditions that’s causing this


drnoobtropics t1_je0zwrd wrote

Oral prednisone can cause osteonecrosis and chindroblast suppression if given long term. Like you said we tend to only prescribe it in severe asthma (stage 5) or in very short courses with eczema. Inhaled (given in asthma) and topical (skin conditions) don’t have this side effect. If the study’s findings are accurate there is most likely another factor(s) causing this, but no doubt the small population of asthmatics taking orals long term aren’t helping this statistic. At the end of the day though, joint pain > dying from hypoxemia. Ez trade


mattmahoneyfl t1_jdyz1bl wrote

Eczema and asthma are both autoimmune diseases. It suggests that either osteoarthritis is an autoimmune disease (like rheumatoid arthritis) or that immune suppressing drugs cause it.


S1umL0rdAkr0n t1_jdz06tp wrote

Copious amounts of prednisone and or stimulants. It's not good for the body...


PBandJ_160 t1_je1nfvg wrote

Great, so I got that look forward to


KetosisMD t1_jdz1vtj wrote

> ⇒ This study demonstrates an association between atopic disease and the development of OA; patients may benefit from the use of treatments that inhibit mast cells and allergic cytokines to treat or prevent OA.

Ketotifen fumarate (Zaditen®; Swedish Orphan Biovitrum) functions as a mast cell stabiliser and has been used as a treatment for chronic idiopathic urticaria because of its antipruritic properties. Similarly, epinastine hydrochloride is both an antihistamine and a mast cell stabiliser.

Within the flavone class, the most active mast cell stabilizers are luteolin, disometin and apigenin. Using anti-IgE to elicit degranulation, luteolin inhibited the release of histamine, LTs, PG2 and GM-CSF from human cultured mast cells (HCMCs) in a concentration-dependent manner (1–100 μM) (Kimata et al., 2000b). Luteolin also suppressed the production of proinflammatory cytokines TNF-α and IL-6 in bone marrow-derived cultured murine mast cells

Glucosamine stabilizes mast cells as well.


[deleted] t1_je0e1jh wrote

42% higher after adjusting for bmi. Still very high and significant but makes more sense to use the bmi adjusted number.


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redbucket75 t1_jdyt2iq wrote

It's hard for me to understand the importance of this correlation - it seems like having any chronic illness makes you more likely to have nearly any other chronic illness.


Sly1969 t1_jdyz3vv wrote

They are all inflammatory / auto immune diseases. That's the link.


Kael_Alduin t1_je14g8h wrote

Heeeey, have chronic, acute asthma for 37yrs now, have had osteoarthritis in my lumbar, and now I'm being screened for RA. ISNT THIS FUN!?


MincedFrenchfries t1_je29pms wrote

I'm not a person in the medical field, so I have no clue how close or far off this question may be. Could it be lack of oxygen and water causing osteoarthritis? Since people with asthma will have a harder time getting oxygen and others with eczema might not hydrate enough.