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thehazer t1_irwdpef wrote

I’d love some more type 1 research please.


Feisty-Requirement t1_irx39hi wrote

I'm type 1 (for 26 years), I'm depressed


0ogaBooga t1_irxpga6 wrote

I've been t1 for about the same. I have zero insulin resistance (new endo actually remarked on how little I take) and I too am depressed.



Mando92MG t1_iryci2v wrote

Me too, for basically the same length of time. Honestly though? I suspect my depression comes from dealing with the symptoms and treating myself more then a direct symptom. I almost never complain but... shots suck! Glucose testing sucks! Dropping low and making an absolute fool of myself crying and shaking sucks ass! Having my muscles get eaten alive by acid because my last vial of insulin cooked in my pocket while walking home after my car broke down SUCKS! It's more then enough to make someone depressed.


dv_ t1_is0wu2k wrote

I believe that the mental aspect of T1D is sorely underestimated and overlooked. There are courses for how to estimate carbs, how to administer insulin etc. to cover the physiological portion. But no one teaches you how to build the mental fortitude necessary do deal with the psychological part. It is no wonder that with a disease that requires daily micromanagement the potential for developing anxiety and depression is much higher.


nowlistenhereboy t1_irxg5jb wrote

It's possible to have insulin resistance as a type 1 diabetic although not every type 1 diabetic has insulin resistance. It's partially genetic. Also partially depends on your diet. If a type 1 diabetic eats excessive calories, they will have to self administer more insulin, and will obviously incur insulin resistance in response to that extra insulin just like a type 2 diabetic does. There is also some effect in the fact that DM1 patients administer insulin into their fat, which seems to result in insulin resistance in the body (periphery) but less so in the core (liver and presumably other organs like the brain too).


Mando92MG t1_iryb5yg wrote

I'm a type 1 diabetic and when I was a teenager and young adult I ended up developing such a high degree of resistance (my ratio was 1 unit for every 3g of carbs at the worst) that I nearly made myself into a type 2 diabetic as well. Genetics has some role to play in that but mostly it was me being a idiot. I got diagnosed at 22 months and by the time I turned 14 I had decided "F*** it" and just started doing whatever I wanted. However by the time I turned 21 after being hospitalized over a dozen times in like 7 years and my kidneys starting to fail. I finally got my s*** back together and started taking care of my self. Now a decade later I've somehow managed to come back from the edge, no protein in my urine and my insulin tolerance is in the average range for a type 1 my age. I bring it up cause I feel it is anecdotal evidence of the effects of varying resistance. A type 2 that let themselves get to that point would have never gotten themselves back to normal resistance levels again.


dv_ t1_is0w3pn wrote

Other people mentioned that there is a known link between T1D and depression, but did not mention any details. I personally don't think this needs to be anything physiological. As a T1 myself, I fully understand the huge potential for depression and burn out with this disease. It is clearly not the "worst" disease in existence (and it is difficult to come up with a metric for defining "better" and "worse" anyway), but it is somewhat special in its sheer relentlessness.

You are required to micromanage it. You need to make sometimes very complex decisions every day, multiple times a day, about administering and deciding the dosage of a hormone that is very potent and can cause you to suffer heart arrhythmia and impaired or even loss of consciousness if the dosage is too high (and what is "too high" and "too low" can be very difficult to estimate), You can end up in "rollercoasters" where your blood glucose level bounces up and down, which, if severe enough, can drain you of all energy and ruin your day. Sometimes your efforts can be in vain - your blood glucose level is just crazy and uncontrollable. And you can't postpone the micromanagement, you can't take a break. This can grind your psyche down easily. Of course not all days are nightmarish like this, but it can get very bad at times. So I am not at all surprised about a clear correlation between T1D and depression, anxiety, burnout. This mental toll alone is already a big enough factor to explain said correlation.


bennynthejetsss t1_irwi2ob wrote

I can only access the abstract so I’m a bit confused. Insulin affects serotonin and decreases symptoms of MDD in Type 2 diabetics? Did I get the jist?


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optimus314159 t1_irykvum wrote

I’ve recently started noticing myself becoming REALLY IRRITABLE whenever I have gone too long without eating.


beatbox2sleep t1_irycgjg wrote

This article proves the necessity of treatment.

Canada just rolled out their medically-assisted suicide program. People are already going for it. Depression and other mental health issues can be treated. Life is worth living.


[deleted] t1_irw1tqz wrote



tr14l t1_irw3rbv wrote

What data are you using to assert it has no effect on diabetics? A link between type 1 diabetes and depression has been established for years. This is contributing in that area.


Mando92MG t1_irw560l wrote

Like the other poster said there is a know link between type 1 and depression. This is talking about insulin resistance though. Which while type 1s can develop insulin resistance it is a key facet of type 2 diabetes. Type ones with insulin resistance used to be called type 1.5 because it effectively having type 1 while also having type 2.


GerassicPark t1_irxbvyr wrote

I thought type 1.5 is LADA?


Mando92MG t1_iry9gvz wrote

I always heard it referred to as delayed onset type 1 by endocrinologists. It is possible it was referred to as 1.5 at some point though. Most of my terminology comes out of late 90s early 00s when I was participating in medical studies for diabetes. I'm obviously still diabetic but I just see a GP now since specialists are expensive and hard to get in to see. So I don't have as much up-to-date terminology and things have changed a lot in the last decade.