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Minute-Object t1_itgfmlh wrote

Reply to comment by Volcic-tentacles in Exploring a new environment helps boost dopamine levels which are projected to the hippocampus, decreasing the threshold for learning. However, in older people, the novelty of a new environment doesn’t boost memory as much as it does in younger people. by Wagamaga

If one uses a dopamine reuptake inhibitor, does that not increase the total amount of dopamine in the neurons and synapses?

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PM-ME-DEM-NUDES-GIRL t1_itisr0f wrote

yes, it does increase the amount of extracellular dopamine and the amount of dopamine neurotransmission (how much dopamine is reaching receptors) but it may not cause a persistent increase in the total amount of dopamine as there are homeostatic mechanisms that decrease dopamine synthesis when extracellular dopamine is elevated and vice versa.

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