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dv_ t1_itfwkpz wrote

Reply to comment by Euda-monia in Association between triglyceride-to-high-density lipoprotein cholesterol ratio and prediabetes: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol | Journal of Translational Medicine by Meatrition

From what I recall, LDL can clog your arteries when it becomes glycated, because then, the liver's LDL receptors don't recognize the glycated LDL molecules and the liver won't take those particular molecules out of circulation. Is this correct?

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OfLittleToNoValue t1_itfyewt wrote

Yep. Glycating happens when there's too much sugar in the bloodstream. Which usually happens when people get put on low fat diets.

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Buttons840 t1_ith9z83 wrote

> too much sugar in the bloodstream usually happens when people are on low fat diets

I would guess the vast majority of people with too much sugar in their bloodstream are not on any specific diet at all.

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Euda-monia t1_itfz5bs wrote

That's part of the picture, yes. There are still a lot of unknowns but what we do know is that both the glycation and oxidation of LDL reduce its ability to be recognised for recycling by the liver. Higher circulating LDL means higher risk of it entering into the artery wall where macrophages gorge on them resulting in foam cells.

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dv_ t1_itg8h7x wrote

When the macrophages pull in the damaged LDL particles, do they ever go away? Are there self-repair mechanisms in the body that clean that up over time?

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