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Grunslik t1_iuloeju wrote

The paper that the article references ( does not single a bacterium out as the possible cause of colorectal cancer. The paper concludes "Indolimine-producing M. morganii caused increased intestinal permeability and exacerbated colon tumorigenesis in gnotobiotic mice. Overall, these studies imply an expanded role for microbiota-derived genotoxins in shaping host biology and disease susceptibility." The title of that summary article is misleading. It's possible that could be due to a translation error (what should be "... a possible cause ..." translated as "... the possible cause ...", but it's misleading nonetheless.


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Vosje11 t1_iumg7ac wrote

Can't you grab a scoop and just scoop all up acid in the tummy and let it reset?


gamma9997 t1_iumk6l9 wrote

The microbiome is so complicated, that unfortunately there is really no "resetting" it. We can try (with fecal microbiome transplants), but in reality once it gets perturbed we can only hope that it returns to something close to normal. You've spent your whole life carefully cultivating this little ecosystem in your gut, if something comes along and wipes it out you have to start over.

It does make me wonder if we should be trying to store our own microbiomes when we get annual physicals so that if something happens during the year we can "reboot" the microbiome with a relatively recent batch.


discretion t1_iuptiq0 wrote

Dang, that's a thing? I got really sick right when the pandemic started, for three weeks, before tests were available. I don't know if it was covid or not, but it was like the worst flu I've ever had, could barely keep fluid or food in me between diarrhea and vomiting. And after I got better, I had a really hard time handling foods I used to eat regularly. It really felt like my whole gut was just mollywhomped and I had to eat bread and rice for a while.


IamreallynotaNPC t1_ium10jt wrote

There is a type of bacteria that eating beef causes to flourish and in turn that bacteria can create LDL. So it may not be the beef itself is bad for the heart but rather the microbiome that flourishes with consuming it.


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greenhairvegan t1_iun1szw wrote

Saturated fat will increase LDL regardless of what bacteria you have, but bacteria that can raise LDL would also be bad for the heart.


priceQQ t1_iumd5a1 wrote

Indolamines are not exactly toxins—they include some very interesting molecules (neurotransmitters). So it may just be natural metabolites of these gut bacteria.


Old_Jellyfish_5327 t1_iuou0we wrote

Digestion is one of the most understudied areas of medicine. Out of all their classes, grad students in medicine spend 2 weeks studying digestion. That's it. Totally nuts, no? Nutritionists are pretty unregulated in the US, and drs that study the colon dont have a lot of tools that they use for diagnosis.


Feralpudel t1_iupbq4p wrote

And it’s hard to imagine a more intricate yet chaotic system. It’s like this million mile heavily trafficked border crossing where it’s crucial to let the right things in and keep the wrong things out.


whattheydontsay t1_iup2m80 wrote

1000% I was in ICU and asked my doctor if I should be eating a special diet. He said diet had nothing to do with it. I challenged him by asking if I could eat nothing but Taco Bell and he said sure, it will have no impact.

A book that became my go-to source, though it has a goofy title, is called Breaking The Vicious Cycle. It was written decades ago and still helped more than any doctor.


cjwidd t1_iuloofy wrote

>Overall, these studies imply an expanded role for microbiota-derived genotoxins in shaping host biology and disease susceptibility.

I think this part doesn't fit the title very well, but it's basically the take-home message.


PansexualEmoSwan t1_iup3k1h wrote

Considering how many other health problems can be traced back to gut permeability, that is the part that sticks out to me the most.