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sonoma95436 t1_ixow5xn wrote

To bad Sprivato the FDA approved ketamine is $800-900 dollars. I spend $100 at the formulary. Drug companies are heartless as the drug has been around since the 60s.


[deleted] t1_ixpbkm1 wrote



Shinbiku t1_ixqrke9 wrote

I know this was meant to be a joke, but I do see a lot of people thinking that using ketamine recreationally will do the same thing. I’m an LCSW that sometimes has patients that go through ketamine treatment and the keyword here is “micro” dosages. Dosages that are pretty much so small that you don’t feel the effects.

Using it recreationally very much will give you the opposite of those benefits that microdoses offer.

There is a whole treatment process that is extremely regulated, including a very comfortable chair and medical staff that monitor the treatment and it’s entirety for a pretty lengthy amount of time.

With that being said, I remember when it was first kicking off, and the doctors at my facility we’re going through training to administer it. I don’t think I’ve ever seen doctors so excited about the results and the research that they read.

It is truly a breakthrough in the right cases, but I wish people took more time to explain exactly what the caveats are to the whole process.


Enthusiastically t1_ixsdf9c wrote

There are multiple models of ketamine administration.

My psychiatrist prescribed me 300 mg 1x per week, which I do at home alone, and I also regularly do IM sessions in office. My at home sessions follow the in office ones in tone, and aren’t recreational, but I definitely get a lot out of it.

These are not so small you don’t feel the effects. The idea in these treatments is to come very close to but not hit the k hole.


SpeakingFromKHole t1_ixst3k2 wrote

Hey there. I have two questions if you don't mind. I have been wondering: Isn't the trip the part that matters? Dissolving set paradigms and axioms is a process relating to conscious thought, is it not?

Also, I never understood why the literature mentions giving benzos to make people not experience trips, but benzos inhibit the learning process, which is why they are great after traumatic events, but in combination with the above question, aren't benzos counteracting the intended effect?

Edit: Also, is a clinic really an enjoyable setting? I would hate to have my experience and concentration interrupted by someone asking how I am doing.


sonoma95436 t1_ixpfssl wrote

It will probably be necessary. Best Wishes


AeonDisc t1_ixqznws wrote

Hopefully ATAI's R-Ketamine will be more affordable, more effective, and with less side effects.


sonoma95436 t1_ixr50md wrote

Current Ketamine is already extremely effective as I was a mess and have not had any real issues since starting it ten years ago. The drug companies are monetizing something that already works and charging ten times more. There is no Rand D needed. That are greedy bastards and only those with health care insurance will be able to afford it.


chrisdh79 OP t1_ixomj9h wrote

From the article: A brain region known as the amygdala could play a key role in predicting symptom improvement following ketamine therapy in patients with treatment-resistant anxious depression, according to new research published in the Journal of Affective Disorders.

“Since the antidepressant effects of ketamine in patients with anxious depression remain unclear, it is necessary to investigate the potential biomarkers predicting the antidepressant efficacy of ketamine in patients with anxious depression,” said study author Bin Zhang of the Affiliated Brain Hospital of Guangzhou Medical University.

“Previous studies have pointed out that functional connectivity differences in the amygdala are linked to depression improvement after ketamine treatment in depressed patients, but their role in anxious depression patients is uncertain. Therefore, we investigated the correlation between depression improvement after ketamine treatment and amygdala functional connectivity in anxious depression patients.”

For their study, the researchers examined neuroimaging data from 31 patients with anxious depression and 18 patients with non-anxious depression.

The researchers only included participants who had a diagnosis of major depression without comorbid psychotic symptoms, had a score greater than 17 on the Hamilton Depression Rating Scale, had previously failed to improve after at least two antidepressant treatments, had completed fMRI brain scans, and had undergone six ketamine infusions.


Gayfunguy t1_ixp0o6z wrote

This is what i need to be better? Ketamine? Dam....well i think it will be easier to get mushrooms.


ScienceOverNonsense t1_ixrtdtu wrote

I had similar experience with mushrooms and PTSD. Microdosing led to subsequent improvements in my PTSD without the unpleasant side effects while under the influence that I experienced with low and moderate doses. Dosing mushrooms is tricky though.


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Balthasar_Loscha t1_iy2j1qc wrote

The Ketamine effect also seem to be dependent on rising IGF-1 level in the CNS, atleast in rodents. Maybe Somatropin injections are the real deal here.