You must log in or register to comment.

SunCloud-777 OP t1_iv93khu wrote

  • A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching implications for the development of antibiotics.

  • They undertook a microscopic examination of the outer membrane of E. coli to understand the molecular basis for the protection it affords against many classes of antibiotics. E. coli causes infections such as pneumonia, UTIs and sepsis that are notoriously difficult to treat due to multidrug resistance.

  • The outer membrane is composed of two types of lipids that stack on top of each other, an unusual arrangement, responsible for making the membrane resistant to antibiotics. the outer membrane contains numerous proteins which the bacterium relies on to acquire nutrients and excrete waste products.

  • By tagging the outer face of proteins within the outer membrane with photoreactive chemicals, they found that not only was each protein surrounded by a ring of stacked lipids but that these lipids were shared with neighbouring membrane proteins.

  • Even more surprising was the finding that the resulting network of promiscuous protein-lipid-protein complexes spans the entire bacterial surface and embedded within it hexagonal lattices reminiscent of those used to strengthen protective body armour.

  • Professor Kleanthous explains. ‘Every protein appears connected to every other protein in the membrane by a network of lipids, creating cellular armour plating that researchers will need to take account of in future antibiotic design.’


[deleted] t1_iv951f5 wrote



SunCloud-777 OP t1_iv95zm8 wrote

well, the ever increasing drug resistance of these gram neg bacteria are becoming more problematic. hopefully with this findings, the drug makers can readjust their anti-biotic design bearing in mind the OM/OMP configurations.


AutoModerator t1_iv92yh0 wrote

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will continue to be removed and our normal comment rules still apply to other comments.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.


51674 t1_ivboc4a wrote

Easy we just gonna arm antibiotics with armor piercing munitions