Viewing a single comment thread. View all comments

TheMailmanic t1_ivbcspp wrote

Reply to comment by basmwklz in Metabolic and physical function are improved with lifelong 15% calorie restriction in aging male mice (Nov 2022) by basmwklz

What does 15% cr mean exactly? Is that 15% relative to ad libitum? Or 15% relative to maintenance calories?

20

r0botdevil t1_ivbs5um wrote

That's what I'm wondering as well, but it has to be the former as the latter would invariably result in death by starvation over the long term.

24

TheMailmanic t1_ivbsqld wrote

Yeah agreed the calorie intake must be at maintenance or above to avoid starving and losing weight continuously.

In terms of applications to humans, it seems like maintaining weight at a low-ish body fat % with resistance training to maintain lean mass results in the best health outcomes generally. Calorie intake has to be adjusted depending on whether you’re trying to lose/maintain/gain

8

Okay_Try_Again t1_ivdpxmu wrote

You don't keep losing weight if you sustain a calorie deficit, your metabolism adjusts to match what you take in, among other factors. That is why 95% of people who restrict calories or increase exercise to lose weight regain within 3-5 yrs even when they keep it up, in reality 2/3 of dieters end up at a heavier weight than they started after 3-5 yrs.

−7

TheMailmanic t1_ivdq8yo wrote

Well yes your bmr goes down as you lose weight Because it’s a function of your body weight to some extent

That said, a calorie deficit is the only real way a person will lose weight over time. The people who rebound are the ones who do extreme diets that they can’t sustain long term. Plenty of people have done slow and steady calorie deficits to reach a target weight then raise calorie to maintenance to maintain that weight

7

Okay_Try_Again t1_ivg1dbo wrote

Not just your bmr goes down, hunger hormones increase as well.

Look at the research you will see that all the studies here a large amount of people can keep off the weight are just one yr long. When you get to a 3-5 yr study, the numbers for people who can maintain the loss are 5-20 percent. And if you have obesity when you try to lose weight the odds go way down, because obesity changes your hormones even further.

1

Concavegoesconvex t1_ive10gj wrote

The problem is that dieters go back to the diet that got them overweight in the first place. Also my personal theory is that people starve-diet themselves, losing muscle in the process, which will indeed lead to less calories burned.

2