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SippyTurtle t1_ivs9092 wrote

Reply to comment by FedXFtw in In a first, doctors treat fatal genetic disease before birth by 29PiecesOfSilver

Generally the defective enzymes don't do anything, and that's the problem. If they don't do what they're supposed to, you don't get the chemical reaction and thus don't get the end product you need. So to answer your question, no, enzyme blockers aren't needed.

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TheXtraReal t1_ivspcir wrote

This. I cannot speak on the article directly ,I am not a doctor.

I have a rare medical syndrome. I produce an excessive amount of histimine (MCAS) but my body no longer produces the enzyme in the digestive tack, so I cannot process histimine. I'm under 40 in age.

This results in, almost all the time just me, being allergic to me. DAO help, for my specific aspect but it's not 100%, more like maybe 30-40%>.

Recap, outside of my over production. I cannot produce the enzyme to combat the over production, let allow normal levels. So when I eat, more often than not. I go into sezuires and anaphylaxis.

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SippyTurtle t1_ivsr63k wrote

That's awful. I've had one patient with it as well so I'm a bit familiar with the condition. My understanding is that it's not so much overproduction as much as it's the mast cells being super sensitive to everything. Are there certain foods you're able to tolerate or do you have to survive on specific nutrition supplements?

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TheXtraReal t1_ivtrlwg wrote

I am reactive to food. I'm still on my journey to learn and document but that's an exhausting task.

I also react to smells, like smoke and various other environmental aspects.

I don't eat much, say in an episode state. I've dropped 30lbs since March '22.

Another fun bit is it was confirmed I also had a rare water allergy. I found a high pH water I can consume but is hard to stay hydrated.

I don't react to orange juice, soooo yummy!

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EriAnnB t1_ivspypv wrote

Jeeezus, that sounds like a tough way to live.

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madcaplarks t1_ivsqekc wrote

Well this is reddits chance to turn this person's problems into the start of an elaborate Four Yorkshireman sketch!

Oooh luxury, when I eat, my stomach comes completely out of my backside and I have to use sharp implements to jab it back in again.

Sharp implements?! Oooh that'd be lovely, I have to have Charles Dance step on my fingers using boots covered in dog poo, then use my crippled pooey splintered fingers to rub gravel out of my eye balls.

Eye balls?! We DREAMED of having eye balls

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