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OliQc007 t1_ivu8i53 wrote

How do the enzymes penetrate the cell ? Aren't they too big to ever get in, even through transporters ?


bigglyboblee t1_ivv3wre wrote

You are right that a limit of ERT is it’s penetration to particular tissues/cells.

However, transporters are not the only mechanism for cellular entry. Have you heard of receptor-mediated endocytosis?

You can check out this paper if you want to see the mechanism in more detail