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dv_ t1_ivudq0d wrote

As a type 1 diabetic, I don't think this is very relevant for treating diabetes. The VX-880 trial already used stem cell derived islet cells (that's not the same stem cell therapy as the one described in the article), so the need for donor cells will go down. Those grown islet cells won't have rejection problems because they would be a match to the patient's body.

A cure for type 1 diabetes requires two big steps: First, cells have to be lab grown (already done in the VX-880 trial). Second, the faulty autoimmune reaction needs to be fixed, or the islet cells need to be encapsulated somehow. Otherwise, the immune system kills off those cells again. The approach described by this paper would not help, because those islet cells would be the patient's own already, so there would not be any "hybrid" immune system. It would not make sense. Also, procuring donor islet cells is difficult and wasteful - another reason why lab-growin islets instead is a much better approach.

However, this is of big interest for organ transplants. People with those have to take immunosuppressants, which are no joke.


noobie107 t1_iw01c8g wrote

why do cells have to be lab grown?

it's also shown that allogeneic stem cell transplant can treat many autoimmune diseases.


dv_ t1_iw0jj25 wrote

Because you want functioning islets that produce insulin.


noobie107 t1_iw0mw8h wrote

maybe you misread the article. they transplant islets and bone barrow from a donor which function just fine. they don't reuse recipient islets


APowerBlackout t1_ivtk2c6 wrote

Please!! It’s been “5 years away” for so long man. They’ve gotta be so close, this would be so incredibly life-changing.


Opinions2share t1_ivwgk6p wrote

Probably happen pretty soon after low cost insulin is an option


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tinfoiltophat1 t1_ivt8sgx wrote

It's something of a joke in the diabetes community how the cure has been "just 5 years away" for the last 30 years. Maybe this will be the one that actually is 5 years away.


NoMoreF34R OP t1_ivt9dgk wrote

I felt this when linking the post. Hopefully, something sticks.


ricric2 t1_iw1u7cr wrote

Just me or does the image attached to the post look super three-dimensional?