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basmwklz OP t1_iw69yjy wrote

Abstract: >Animals must adapt their dietary choices to meet their nutritional needs. How these needs are detected and translated into nutrient-specific appetites that drive food-choice behaviours is poorly understood. Here we show that enteroendocrine cells of the adult female Drosophila midgut sense nutrients and in response release neuropeptide F (NPF), which is an ortholog of mammalian neuropeptide Y-family gut-brain hormones. Gut-derived NPF acts on glucagon-like adipokinetic hormone (AKH) signalling to induce sugar satiety and increase consumption of protein-rich food, and on adipose tissue to promote storage of ingested nutrients. Suppression of NPF-mediated gut signalling leads to overconsumption of dietary sugar while simultaneously decreasing intake of protein-rich yeast. Furthermore, gut-derived NPF has a female-specific function in promoting consumption of protein-containing food in mated females. Together, our findings suggest that gut NPF-to-AKH signalling modulates specific appetites and regulates food choice to ensure homeostatic consumption of nutrients, providing insight into the hormonal mechanisms that underlie nutrient-specific hungers.


Chiliconkarma t1_iw6ioeo wrote

I wonder how efficient that method of "diet" would be.


curiousfirefly t1_iw6p5pe wrote

It surpresses sugar cravings, but promotes storage of fats. Depends on the balance of these effects, but I'm guessing it'll end up cancelling eachother out.


myurr t1_iw6qpre wrote

I guess it depends if it helps break an addiction and leads to better long term eating. A month or two of gaining fat to change long term diet into a healthier one once off this hormone would be a worthwhile exchange for many people.


SensitiveTurtles t1_iw721qj wrote

Isn’t “promoting storage of fats” the same as saying “reduces glycogen available for muscles and brain”? So would this lead to lower energy levels? Seems like we’re attenuating one of the only benefits of fast absorbing carbs.


RedditIsDogshit1 t1_iw6yoz8 wrote

Doesn’t that sound exactly like the sort of thing somebody wishing to enter ketosis would be seeking?


kkngs t1_iw997d3 wrote

Other way around, they want the fat cells to be releasing energy not storing it, I think?


seehp t1_iw6t75s wrote

Advertisements are stronger. We should ban them first and I would expect quite a change.


_DeifyTheMachine_ t1_iw6vlif wrote

Exactly. Disgusts me that we allow companies to plaster all their products in vibrant colours, mascots, questionable wording. The kids are especially vulnerable to this sort of advertising. And ironically kids food are some of the most unhealthy, especially in terms of how calorie-dense they are.


wwiybb t1_iw74zsv wrote

That and trying to find food without sugar. There are about 20 different names for sugar and they all use it to conceal what's in the food. Wife had to do a sugar free diet one time holy crap what a pita it's in everything.


DocRedbeard t1_iw6zn48 wrote

This is basically how the new diabetic medication mounjaro works. It's a glp-1/gip and it's extremely effective at weight loss.


c0reM t1_iw73lpg wrote

Quite interesting.

I’ve also often wondered if any hormones are mediated by bacteria and other parts of the microbiome.


peoplerproblems t1_iw77u4e wrote

So what makes this work differently than a GLP-1 agonist? everything hear sounds like this is another potential weight-loss drug by a well known mechanism


1saltymf t1_iw9vgi9 wrote

> These NPF-induced changes in food intake were likewise not associated with altered triacylglyceride (TAG) or circulating sugar levels (Extended Data Fig. 1l,m), supporting a direct role for gut-derived NPF in governing feeding behaviour, rather than effects of NPF on metabolism that then lead secondarily to altered behaviour. Together, these results indicate that NPF from these EECs is both necessary and sufficient to inhibit food intake and prevent food overconsumption.

GLP-1 agonists alter insulin patterns and average blood sugar, in addition to appetite suppression and modifying feeding behavior.

Seems like this drug, analogue to NPY in humans, mainly affects feeding behaviors.


thevalahian t1_iw8h93i wrote

Those melanogasters were always binge eaters, good they found a solution.


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Hillaregret t1_iw83fmx wrote

I'd make an existential wager on the accumulation of evidence for similar mechanisms influencing metabolic pathways in human appetite.