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basmwklz OP t1_iw6aqnq wrote

Abstract: >Background: Typical vivarium temperatures (20-26°C) induce facultative thermogenesis in mice, a process attributable in part to uncoupling protein-1 (UCP1). The impact of modest changes in housing temperature on whole body and adipose tissue energetics in mice remains unclear. Here, we determined the effects of transitioning mice from 24°C to 30°C on total energy expenditure and adipose tissue protein signatures. Methods: C57BL/6J mice were housed at 24°C for two weeks and then either remained at 24°C (n=16 per group, 8M/8F) or were transitioned to 30°C (n=16 per group, 8M/8F) for 4 weeks. Total energy expenditure and its components were determined by indirect calorimetry. Interscapular brown adipose tissue (iBAT) and inguinal white adipose tissue (iWAT) proteins were quantified by western blot and quantitative proteomics. Results: Transitioning from 24°C to 30°C reduced total energy expenditure in both male (-25%) and female (-16%) mice, which was attributable to 36% and 40% decreases in basal energy expenditure in males and females, respectively. Total iBAT UCP1 protein content was 50% lower at 30°C compared to 24°C, whereas iWAT UCP1 protein content was similar between conditions. iBAT UCP1 protein content remained 20-fold greater than iWAT at 30°C. 183 and 41 proteins were differentially expressed between 24°C and 30°C in iBAT and iWAT, respectively. 257 iWAT proteins differentially expressed between sexes at 30°C were not differentially expressed at 24°C. Summary: 30°C housing lowers total energy expenditure of mice when compared to an ambient temperature (24°C) that falls within the National Research Council's guidelines for housing laboratory mice. Lower iBAT UCP1 content accompanied chronic housing at 30°C. Further, housing temperature influences sexual dimorphism in the iWAT proteome. These data have implications regarding the optimization of preclinical models of human disease.

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[deleted] t1_iw6b53r wrote

That is an insanely large effect. I would guess that our surface area to volume ratio would drive significantly lesser results, if nothing else. Still it would be very interesting to compare say home heating costs with weight gain at a population level... attempting to control for food consumption/costs of course.

We so often discuss the impacts of cheap food without ever discussing how relatively cheap air conditioning effects us.

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Sparkykun t1_iw6clsi wrote

How much did they pay for this study ?

−7

ElTeliA t1_iw6dv7d wrote

I know you cant conclude this from this article. but, applied to humans, is this saying that if your house is more around 30 C than 24 C you will be more likely to produce and store adipose tissue?

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Rocknerd8 t1_iw6dwlh wrote

So does this mean that having the heating on constantly makes us more disposed to gaining weight because the absence of environmental factors found in nature?

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cowrevengeJP t1_iw6f8an wrote

If it's hot. I sleep. End of study.

Unless I'm hungry or poor at the time.

We already knew this.

It's why I think countries with better weather are legit friendlier.

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tyloriousG t1_iw6h7oq wrote

I'm keeping my house cold idc how the mice reacted.

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Jane-Henry t1_iw6jzny wrote

30C is 86 F that’s really hot! 24C is 72F.

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BafangFan t1_iw6lf5q wrote

Replying to JoeDoherty_Music (#516,914)

Brown adipose tissue is a type of fat that burns fat to generate body heat.

By raising the room temperature by about 12f, rats burned 16-25% less energy than rats kept at the lower temp.

But 12f is the difference between 60 degrees and 72 degrees, and I think we can all argue that 60 degrees is a pretty miserable temp.

To critique the point of the study, people aren't fat because their room is too warm. Look at people in Thailand, India, Vietnam. It's hot as balls over there, and many don't have A/C - and yet those are typically rather lean countries.

On the flip side, NASA astronaut Ray Cronise lost 80 pounds in part through sleeping in shirt and shorts with the window open all year long.

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hhunkk t1_iw6mvtl wrote

I like your funny word magic man

−1

Psycho-Pen t1_iw6mzfk wrote

I had a college professor who talked about losing weight every year when he went hunting for deer during the winter. I suppose they could have just asked him, and saved the money.

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[deleted] t1_iw6nme3 wrote

I keep my house under 18 degrees C. It’s how I maintain my figure. Cold showers, too.

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Dr-Chris-C t1_iw6nvx6 wrote

Is lowering energy expenditure good or bad? Like is it going to prolong their lives or are they just exhausted from trying to stay cool and can't do anything?

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Hopeful_1768 t1_iw6o1ch wrote

the more I see of posts on r/science the more I am beginning to thing that without any added context or classification they don't give science a good reputation.

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myurr t1_iw6uv8d wrote

Replying to oMaddiganGames (#517,474)

And yet she's a block of ice when first getting into bed, leaching your very soul out of your body to give her life again when her freezing feet touch your legs.

Five minutes later and she's radiating more heat than Chernobyl's core.

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tkenben t1_iw6wfsf wrote

I can honestly say I am more lethargic and less comfortable moving around at 30 deg C than I am at 24 deg C. But the article talks about differences in brown fat. I didn't think that the size of the stores would have anything to do with lethargy really, but apparently it might.

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sweerek1 t1_iw6x2pc wrote

In humans I’ve long noticed a cooler house / camp results in far more activity

At the temp extremes … Scouts are lazy sitting in the shade and moving / shivering in cold.

But just a few degrees cooler, think get a sweater while sitting temp, keeps ya moving too.

Maybe I’m part Mouse(keteer)

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Thomas_the_chemist t1_iw6xhjv wrote

Replying to BafangFan (#517,186)

But the temp wasn't that low. 24C is 75F and they went up to 30C which is 86F. Both temps are relatively warm. I wonder why the study didn't move a third group to a colder chamber, like 18C?

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InGenAche t1_iw6z9zf wrote

I swear to god I've had it! Why the hell are we spending so much money and research trying to improve the welfare of mice and not on humans!

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Zerothian t1_iw6zplm wrote

Replying to BafangFan (#517,186)

>and I think we can all argue that 60 degrees is a pretty miserable temp.

Honestly, not really, at least not for everybody. I'm in the UK and that's roughly my ambient in the living room. This is measured by a sensor in my computer case at idle and showing 18c, so realistically it'd be a couple degrees cooler outside the case. It's fine as long as I'm fully clothed, it is pretty miserable if I'm not wearing sleeves and socks though.

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TheButteredBiscuit t1_iw71c17 wrote

All I know is my roommate keeps putting the ac on 65 with the fan on every night and now every morning I struggle to get up because I’m so damn cold

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dvdmaven t1_iw75mpp wrote

If I lower the temperature any more my wife would move out. And, yes, we are both a bit over-weight.

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malppy t1_iw78mgj wrote

Replying to [deleted] (#517,301)

If a study was done it'd probably be attributed to caloric intake and diet. The portion sizes in SEA are super small compared to the west. Northern SEA countries also consume a high amount of veggies in their diet.

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pdonchev t1_iw79hwz wrote

Replying to [deleted] (#516,816)

I would boldly assume that the effect of extra calories from food accessibility dwarf any effects of ambient temperature, within some reasonable range of home temperatures (say, 18-28 °C). It's hard to outrun a bad diet, I bet it's even harder to out-shiver it.

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DependentPangolin911 t1_iw79m38 wrote

Replying to grewapair (#518,302)

Thermoneutral zone for mice is around 30 deg C, so they may well have been at 75 deg. There’s a long standing argument that mouse rooms are kept too cold for mice for the comfort of humans, which is likely impacting their behavior and experimental results.

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westhewolf t1_iw7a342 wrote

Replying to Divers_Alarums (#517,933)

Yah, makes sense to me. We aren't mice. We can change our clothes and have other strategies to stay warm, which generally involve being sedentary. Mice on the other hand have no choice but to move around and shiver to stay warm.

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The_Noble_Lie t1_iw7bnhu wrote

Sleep with window open, no matter the winter season.

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Gozillasbday t1_iw7gf1t wrote

Replying to cowrevengeJP (#516,972)

Speaking as someone from the US, outwardly the South and warmer states may outwardly act nicer, but in reality they are not. The cold places are just more no nonsense, but actually mean it when nice.

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love2Vax t1_iw7oeek wrote

Replying to JoeDoherty_Music (#516,914)

We use mice as an animal model for medical research before we test the same thing on humans. The current recommendations is to house them at 24C. This experient was questioning how housing them at a warmer temperature might impact the results of the experiments we do before human trials. Questions about how a new drug is metabolized in mice before we test it on humans can have big implications if we aren't testing the mice under the correct environmental conditions.

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Nauin t1_iw7t0gz wrote

Replying to Divers_Alarums (#517,933)

That makes sense with how crazy adaptive our bodies are, of course it would start storing fat to better insulate our organs and keep them working in cold environments. Pretty much every mammal in arctic or tundra environments have a big layer of fat or blubber for protection.

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esotericenema t1_iw80vbl wrote

Sweating a lot is known to make you lose weight, too. Hence the reason wrestlers use saunas so much. So, extreme temperatures, in either direction, will probably do it. What would be even more interesting would probably be trying to figure out if there's a difference between extreme heat and extreme cold, in terms of the exact kind of weight you're losing, in terms of actual fat vs. water weight or muscle.

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Fauglheim t1_iw83wky wrote

34% reduction in basal energy expenditure for male mice and 40% for female mice.

Wow!

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Mutha23tucka t1_iw8uxnn wrote

I'm not getting much more of a conclusion from this than colder temps in your home result in more body movements which results in higher whole body expenditure and adipocyte thermogenesis capacity. Please correct me if I'm wrong.

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bigspicycucumber t1_iw90m3d wrote

Replying to Rocknerd8 (#516,927)

I had the covid booster and my lymph nodes were huge! I went camping and spent the whole night shivering. I woke up the next morning and the lymph nodes were gone. I attributed it to increased metabolism (e.g. blood flow, lymph drainage) but this source is nice to back it up.

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