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Relevant_synapse OP t1_iyd1dof wrote

Reply to comment by sockalicious in Alzheimer’s Drug In Development, Lecanemab, May Benefit Some Patients But Carries Risks of Brain Swelling and Bleeding by Relevant_synapse

If you go back to the trial protocol, the participants’ MRIs had to have <4 microhemorrhages in order to be enrolled. Known CAA would have been a contraindication to even being in the trial. It’s reasonable to believe that there was no indication that this woman had CAA before she received tPA and all hell broke loose, but we obviously won’t know for sure until the case report is published.

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sockalicious t1_iyd2z8h wrote

I have rarely seen such a dramatized account of a medical complication in a science journal, by the way. When folks die in cancer trials, is it commonplace to describe their screaming, or the visit of the priest to the bedside?

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Relevant_synapse OP t1_iyd3hpx wrote

People don’t tend to die from massive brain bleeds in cancer trials. The priest visit depends on the patient’s religious beliefs, but is pretty commonplace in my experience as an ICU physician.

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sockalicious t1_iyd3x66 wrote

I am a neurologist. People do indeed die screaming on the cancer ward, happens all the time. My point was just that it's a little odd to find these details in a science journal article about an investigational drug.

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Relevant_synapse OP t1_iyd430n wrote

I am also a neurologist, but my patients tend to die intubated since I’m neurocrit. This piece hit close to home because it’s literally what I do, and unfortunately what you think may be a dramatic description I see in daily life.

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