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Antivax head gonna explode 15 years from now when 80% vaccines are mRNA

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I hope they are super focused on mRNA vaccine against Hepatitis C

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If we all had rabies protection, there would be no more transmission, so it only makes sense that all of us needs to get protected asap. I'm assuming it's safe but definitely sounds effective. Since it's looking like the last mRNA vaccine needs to be updated yearly, I'm guessing this one will be too?

Most rabies isn’t person to person but from wild animals to people. It’d be a great first line of defense but we’re unlikely to eliminate rabies itself.

I actually meant wild animals to human transmission, but thanks for the clarification. And yes it would be a great line of defense. 60,000 people die every year from rabies, so everyone needs to get vaccinated to help make sure that number is as close to zero as possible.

We live in amazing times.

They're going to explode in a couple years when governments are spraying aerosol mRNA rabies vaccines aerially over forests and I'm all for it

100%, it’s a horrible way to go. 0 would be the perfect number.

Nah, they're just going to forget about ever having a problem with it, but then repeat the exact same process for whatever technology is new at the time.

While rabies is the most terrifying ailment humans have ever encountered, infection in humans is incredibly rare. The vast majority of transmission is within the wild.

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When I got scratched by a stray cat (one of the least likely to infect humans) I still didn't take any chances.

When I went to the hospital to get innoculated I saw a video on screen about rabies and was glad to eliminate all probability.

Until the next transmissible spongiform encephalopathy develops to be even more virulent - kinda like 28 days later and the rage virus - these are more common than you might think, commonly known as prion diseases, and can even be induced by some biologic drugs used to treat chronic illnesses

Only those who haven't died already from some preventable disease.

Extremely accurate. Social media a prime example -- boomers have finally accepted Facebook.. as it dies. But are vehemently against Instagram and other platforms for the same reason they didn't like Facebook in 2008.

I'd hate to constantly be behind the curve man.. I dunno

Yup. They'll be afraid of the 6g towers and claim 5g is safe.

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> Since it's looking like the last mRNA vaccine needs to be updated yearly, I'm guessing this one will be too?

The last one needs to be updated yearly because the virus it fights against is constantly changing, and we need to address the new versions of it. As far as I know, rabies doesn't change a whole lot, so updates would need to be far less frequent. Possibly something more like Tetanus shots, where once a decade or so just to remind your body of what it is, would be plenty.

Note that everything beyond my first sentence is guessing and conjecture, and I don't do anything medically-related for a living.

Don’t we already have a perfectly reasonable vaccine for the Lyssa virus?

Same thing we saw with seatbelt and helmet laws in the 80s.

Lyssa, but yes. I'd have to do some research, but perhaps they're hoping for longer duration immunity with lower risk of side effects (there aren't many to begin with and immunity is pretty long-lived already).

The most vexing thing is that mRNA vaccines so far have needed very good cold chains. Most of the human cases of rabies, where the most benefit from vaccination would be, are in developing areas where cold chains are much less practical.

I had no idea it was this high worldwide. It looks like vaccination programs would be most needed in Africa and SE Asia.

Thanks for the correction on the name. I often post lazily in my barely conscious morning brain and get lazy.

I think I might love an elaboration if you had time. Cold chains is a new concept to me.

By then they'll all be dead from preventable diseases

Sure! Remember during the COVID vaccine roll-out, the vaccines had to be kept frozen, and could only sit for 15-30min when removed from the freezer? It's been updated a bit based on field experience and trials, but you can find more info here.

Essentially, mRNA is fragile at room temp. It needs to be kept frozen or cold for long periods of storage. Developing areas won't necessarily have the equipment to keep the vaccines cold.

It's why the oral poliovaccine, which is stable at room temperature (though runs the risk of reverting to a virulent form of the poliovirus) is used so commonly in sub-Saharan Africa and India, whereas the rest of the world uses an inactivated poliovaccine that isn't as stable at room temperature.

As someone who has had the rabies vax, can we maybe just maybe get it to where its less than 12 gigantic needles in the whole thing spread out over a course of a month? First day for a 210 lb person is 8 shots(2 in each arm & leg). After that you still have 4 to 5 left over the course of a few weeks as boosters.

Dont get me wrong... Human Pincushion better than Rabies death but damn is it a rough time and inconvenient as hell to go to an emergency service every time for a booster

You can also wait for them to start studying the side effects a year after they've already given people the shot.

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No idea where you got your treatment. It should be 4 injections over 14 days.

I just recently learned how deadly rabies is! By the time you have symptoms you are ~90% likely to die. Roughly 6% of people who live have a weird immunity they still haven’t figured out. This is amazing. I hope it can be used in humans quickly.

It is more like %99.9 and only 6-7 persons got away with it but doctors are not sure they were infected with rabies. So you can say that it is %100.

That is severely downplaying the virus. If left untreated, it's safe to say that 100% of patients die. As far as i'm aware of, only 3 people survived, all left with serious health problems. Google "Milwaukee protocol". So saying that it's around 90% is like saying there's a chance. There isn't. If assumed exposure do not hesitate to get shots.

Dont know what you did but i just got mine and it was 3 regular vaccines over a week

Thanks for the correction

No worries mate, once i was pretty scared due to a dog bite so i always care about right knowledge about rabies. Nasty stuff.

I recieved mine via a local ER eho said the vax available was weight based. The first 8 were due to that an each one counted as a booster. I was told this is standard

Those poor little beagle pups.

Radiolab has a good episode on it. They mention that there are some people with natural immunity to it.

You can find more on it in this journal.

So unfortunately, even having had HCV doesn’t provide any protective immunity. So that one might be a “no can do.”

But we can cure HCV, so that’s a thing.

I know there's someone in here thinking "I'll take my chances with rabies"

Oh that 6G stuff is evil. It'll make your hemorrhoids grow molars of their own

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Those were antibodies injection, not vaccines (or possibly some injections were vaccines but most weren't).

The injection given after a possible exposue is antibodies AND vaccines.

The one done preventively are just vaccines. those are small injecton, just like a flu shot (typically 3 injections weeks aparts).

In cats, we have genetically modified (recombinants) Rabies vaccine. What they did is genetically modify a benign virus (canary pox) for it to express surface proteins of rabies.

While this is not a Mra vaccine, it's still a better vaccine than the traditional killed vaccine. It'S also a very advanced vaccine technology. They even made a similar vaccine for a retrovirus (Feline leukemia) which is something in the same general group as the AIDS virus in people. The recombinant vaccine are also much safer than traditional vaccine (in cats at least).

Funny annecdote, when they tried to get the vaccine approved for 3 years, they failed the studies 2 times (get got it on a modify protocol on the 3th try). Not because the vaccine failed, but because the live vaccine probably spread to the control patients. None of the control contracted Rabies after 3 years even if they didn't get the vaccine injected. The vaccine was so good and would work even if spread naturally that it kept causing failure.

Right the protocol for survival is also... barely surviving, with extensive damage

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I thought the theory was that the virus wasn’t strong enough, not that the vaccine spread to the other animals?