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FantasyThrowaway321 t1_ixt9yr7 wrote

Well said, I’ve been clinically/severely depressed what now appears to be my entire life with ~15 of therapy, many medications, plenty of other attempts/ideas, and even today with my therapist I had a new ‘breakthrough’ or moment or tendril or whatever. It doesn’t stop, and you never know what another is wrestling with even during their greatest perceived successes. ‘It’s complicated’, well said


Catinthemirror t1_ixuk8yx wrote

With the usual caveat of a grain of salt to accompany advice from an internet stranger, have you been tested for the MTHFR genetic issue with methylation of folates? It can result in drug-resistant depression but is in itself treatable with supplements. I only suggest it because "lifelong" depression is a flag; my son and I both have it. Feel free to totally ignore this info.


ZippytheKlown t1_iy3x02s wrote

Yup! I have this and I was prescribed Spravato (esketamine) for major depressive disorder


twelveski t1_ixun323 wrote

What is the best way to test for that?


hepakrese t1_ixyw0i7 wrote

Ask your therapist/doctor about genetic testing to help identify medications or therapies that may be more or less likely to be helpful for you and your issue. The tests may help shed light on how your body processes chemicals in each medication. Some are metabolized quickly or slowly, others not well at all, which affects how well you respond to the medication and at dosages. There are variations for other conditions and medication types.

I've had severe depression many times in my life and tried upward of 20 medications with intolerable side effects. The genetic testing corroborated what I knew: most don't affect me like intended, so just don't. Don't bother prescribing ::gestures broadly:: those ones.

It doesn't tell you what will cure you, but it may help inform decisionmaking during conversations with your care team.