You must log in or register to comment.

Eastern_Ad_8086 t1_j1rfwwq wrote

Welp, now someone rich is going to start shoving baby poop up their chute.


AllanfromWales1 t1_j1qtxuj wrote

There was a recent paper that said gut microbiota transplants only had a transitory benefit in the overweight and that after a few months the gut reverted to its old microbiota composition. Does this suggest a different conclusion, or is it maybe species dependent?


-JPMorgan t1_j1szme3 wrote

Depends of course on how the transplant is done, but taking a pill every few months sounds like an absolutely easy treatment.


MaximilianKohler OP t1_j1r1u6d wrote

There is a lot to still figure out with FMT. Most studies have severe deficiencies in donor quality and treatment length. Completely replacing an existing and very complex ecosystem isn't simple.


Attila_the_Hunk t1_j1rc7xi wrote

One thing I'm super curious about: my dad doesn't have an appendix- he was born without one. If the appendix does act as a sort of reservoir for gut microbiota, I wonder if he would have more success with FMT than others who do have an appendix.


[deleted] t1_j1qvjuh wrote



MaximilianKohler OP t1_j1r1nta wrote

Most of that is not true. There's a wiki stickied in my profile that has a page on Aging, which debunks much of those claims. The "Intro" and "FMT" pages also have many studies showing long-term benefits.

There is a bi-directional pathway where environment can affect the microbiome and vice versa. But most studies show that the symptoms stem from the changing of the gut microbiome, and restoring it via FMT can reverse symptoms. Changing environment is much more limited, which is why FMT is being heavily researched as a treatment for numerous conditions.

There are many factors that need to be figured out, such as identifying ideal donors, and methods to completely replace the existing microbiome.

Our gut microbiomes have evolved alongside us for a millenia, and get passed down generationally. We're doing significant, permanent damage via antibiotics, lack of breastfeeding, junk diets, and more And these extinctions may only be reversible with FMT from the few people who are not yet damaged.


MaximilianKohler OP t1_j1qt9jx wrote

> Background > > Aging is a natural process that an organism gradually loses its physical fitness and functionality. Great efforts have been made to understand and intervene in this deteriorating process. The gut microbiota affects host physiology, and dysbiosis of the microbial community often underlies the pathogenesis of host disorders. The commensal microbiota also changes with aging; however, the interplay between the microbiota and host aging remains largely unexplored. Here, we systematically examined the ameliorating effects of the gut microbiota derived from the young on the physiology and phenotypes of the aged. > > Results > > As the fecal microbiota was transplanted from young mice at 5 weeks after birth into 12-month-old ones, the thickness of the muscle fiber and grip strength were increased, and the water retention ability of the skin was enhanced with thickened stratum corneum. Muscle thickness was also marginally increased in 25-month-old mice after transferring the gut microbiota from the young. Bacteria enriched in 12-month-old mice that received the young-derived microbiota significantly correlated with the improved host fitness and altered gene expression. In the dermis of these mice, transcription of Dbn1 was most upregulated and DBN1-expressing cells increased twice. Dbn1-heterozygous mice exhibited impaired skin barrier function and hydration. > > Conclusions > > We revealed that the young-derived gut microbiota rejuvenates the physical fitness of the aged by altering the microbial composition of the gut and gene expression in muscle and skin. Dbn1, for the first time, was found to be induced by the young microbiota and to modulate skin hydration. Our results provide solid evidence that the gut microbiota from the young improves the vitality of the aged.


BeginningTower2486 t1_j1sj1dq wrote

So rich people gotta stop drinking the blood of virgins, and switch to *checks notes* cannot complete that sentence.


spinjinn t1_j1slu3d wrote

Yet, did I not just recently read a study which showed that fecal transplants from thin people do not help obese recipients?


MaximilianKohler OP t1_j1t4drx wrote

Yep. There is a lot to still figure out with FMT. Most studies have severe deficiencies in donor quality and treatment length. Completely replacing an existing and very complex ecosystem isn't simple.


AutoModerator t1_j1qt54g wrote

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.


squashblossom666 t1_j1tgjqb wrote

It’s this an advertisement for poop transplants?


MrSnowden t1_j1tyya5 wrote

Nah, we gotta start eating baby entrails.


ThatOneGirlStitch t1_j1wtqjc wrote

So it's not as simple as using stools and getting better. But if it is high quality donor and you do the correct treatment length, still nothing is guaranteed? Does that mean that there is a low chance of it working, do to the fact we are in the early stages of research?