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GETitOFFmeNOW t1_j1zpnoe wrote

Reply to comment by FlashMadalyn in Scientists develop blood test for Alzheimer’s disease by grab-n-g0

I've been reading about a lowercase diet for Alzheimer's where the key factor is decreasing brain insulin resistance. Re: type 3 diabetes.

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FlashMadalyn t1_j20ae0b wrote

Ya I've been hearing about that for some time.

What I think is likely more impactful is lowering saturated fat for people with the Alzheimers gene (Apoe4) -- the highest sf consumers are 1100% more likely to develop dementia than the lowest sf consumers (among Apoe4s)

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GETitOFFmeNOW t1_j20dj2f wrote

It's not the fat, it's the excess carbs, which become too much glucose that causes the brain to be insulin resistant.

Saturated fats can be really good for you, especially if they contain medium chain fatty acids which creates ketones without being in ketosis. If your brain can't take up glucose properly, feeding it ketones will keep it going. It works so well it can have a huge impact on epilepsy and c ommin brain fog.

Check out this 2002 article from Gary Taubes in The NYT magazine. He makes some points that still stand 20 years later.

I gather you've been to Google Scholar and read up on the abandoned type- 3 diabetes data? It's eye-opening. The AMA seems completely uninterrsted in non-pharmaceutical remedies.

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FlashMadalyn t1_j20dt08 wrote

Um it's definitely the saturated fat. I've got the study I can link it later. Apoe4s have different lipid metabolism.

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GETitOFFmeNOW t1_j20fsrk wrote

Yes, we take a much longer time to get into ketosis than people without the APOE4. An issue with low liver production of certain enzyme.

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