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SwansonHOPS t1_j2fdzus wrote

Reply to comment by Gastronomicus in Intensity of psychedelic experiences after taking psilocybin does not depend on body mass index, study suggests by nikan69

>It is likely that the minimum dose to achieve this effect varies by mass.

Why do you say this is likely?

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Gastronomicus t1_j2fjt6b wrote

For the same reason I gave here:

>But the 100 kg person is larger and almost certainly requires more of the same drug to achieve the same blood concentration.

More mass = higher necessary dosage. A greater volume of blood/body fluids means a more diluted product in the bloodstream. Beyond a certain dosage the effect might be similar because you've saturated the receptors. Not sure that applies here or not, probably not since higher dosages are linked to more intense experiences.

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SwansonHOPS t1_j2flbeq wrote

The only two drugs I know of that are mass-dependent are DXM and alcohol. Where are you getting that, in general, more mass = higher necessary dosage?

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