You must log in or register to comment.

SciGuy45 t1_izwh36s wrote

A distantly related virus that happens to use the same receptor isn’t neutralized by CoV-2 antibodies. How is this a big deal, especially when Omicron is resistant to many monoclonals?


Reasonable_Ticket_84 t1_izwxlxv wrote

It isn't, this is just normal research cataloging observations and discoveries for the pile. Someone in the future in a Sarbecovirus outbreak if it ever happens, can look back at the human knowledge built up over time.


SciGuy45 t1_izx5za4 wrote

I’m a HUGE fan of basic research. What I dislike is overhyped conclusions.

“While these two viruses are in a viral lineage distinct from SARS-CoV-1 and -2, the RBD from one virus, Khosta 2, was capable of using human ACE2 to facilitate cell entry. Viral pseudotypes with a recombinant, SARS-CoV-2 spike encoding for the Khosta 2 RBD were resistant to both SARS-CoV-2 monoclonal antibodies and serum from individuals vaccinated for SARS-CoV-2.”

It’s not very interesting to randomly test the cross reactivity of antibodies to unrelated viruses. It’s much more important to understand the receptor:RBD dynamics. As a former journal editor at a different journal, I’m surprised this got into PLoS Pathogens.


red_purple_red t1_izx1kqm wrote

Which bats did the SARS-CoV-2 virus originate from?


sklb t1_izy2u2f wrote

the one from blueprint probably


AutoModerator t1_izw9dco wrote

Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.


ghulo t1_izwoj7h wrote

Dear Chinese, please don't go to eat them.