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UniversalMomentum t1_j00wya6 wrote

Antibodies persisting doesn't mean immunity and the levels of antibodies vary too much from person to person.

Having antibodies for 12 months still might mean you're only immune for 6 months and that can vary from one to six months or from one to 12 months which winds up not being useful enough information to build policy around.


watabadidea t1_j02kgcf wrote

>...which winds up not being useful enough information to build policy around.

Maybe I should ask what level of accuracy you think has been used to build public policy up until now. I mean, the current public policy is to recommend the bivalent booster to everyone over the age of 5 that is at least 2 months out from their last vax.

What level of information you think was used in making that recommendation? I seriously doubt they have accurate information and modeling showing antibody levels and corresponding immunity over a 12-month period for a large population.


[deleted] t1_j00v946 wrote

Damn. I must be super unlucky. I've had it four times now. Twice in the last 4 months. The last time it was just a few annoying cold-like symptoms, so less intense for sure.


johnleeshooker t1_j01mixo wrote

Read up on T-cell exhaustion.


[deleted] t1_j03gbpe wrote

Describes a condition in which T cells (a type of immune cell) lose their ability to kill certain cells, such as cancer cells or cells infected with a virus. This can happen when cancer, chronic infection, or other conditions cause the body’s immune system to stay active for a long time. Exhausted T cells have high amounts of immune checkpoint proteins on their surface, which may keep the activity of the T cells suppressed. In cancer treatment, drugs that target these proteins may be given to allow the T cells to better kill cancer cells. Learning more about T-cell exhaustion may help in the development of new types of immunotherapy to treat cancer.

Okay, so I'm a hypochondriac already. Are you telling me I have cancer now???!!!


sotoh333 t1_j06hd8q wrote

No, but covid may make your more susceptable to it, and any subsequent infections. Funguses, bacteria, viruses... Including other strains of covid.

It may mostly resolve in a few months. Protect yourself.


Joshua-Tyler-Berglan t1_j035qtn wrote

And then get cd4 and cd8 counts checked


[deleted] t1_j03hiws wrote

My bloodwork always comes up with a few things out of normal range, but my doctors always say that when not combined with other skewed results it's not anything to worry about. If I get this checked, it will probably be off but they will tell me it's nothing to worry about. I'll then continue to be a hypochondriac and look up every type of cancer I probably have.


Joshua-Tyler-Berglan t1_j03s0e8 wrote

I am praying for you


[deleted] t1_j07ugb8 wrote

I'm not a religious person, but I think I do need some prayers. Especially this week. I'm usually the most optimistic person anyone knows but on the inside I'm crumbling and am in shambles. I exersize daily to run away from my troubles. Thanks for your prayers. I think all broken people could use a little something. Anything. Thanks again.


lostsoul2016 t1_j00qf32 wrote

Didnt for me. Had Covid in May and then again in August. And i had already had 3 shots by May


SnooPuppers1978 t1_j013p37 wrote

Antibodies could persist, but it doesn't mean you wouldn't get infected again.


HyperAad t1_j00rb8h wrote

Probably had two different strains. Different enough to evade previous immunity.


katarh t1_j06nxvg wrote

Sounds about right. A room mate has had it three times now, and it was a different strain each team. Alpha, Delta, and Omicron in the beginning of November.

I've never had a positive test or any of the classic symptoms, but round about January of last year I had a week of weird leg cramps, and my antibody levels reached Reactive + at my platelet donation, giving me a good indication that I fought off a systematic infection without it touching my respiratory system (where it would be detected by a nasal swab.)


Yotsubato t1_j01uz6g wrote

I got the new bivalent booster in November then promptly got Covid 2 weeks later for the first time…. This thing mutates like crazy


Sigseg t1_j02jowb wrote

I got the latest booster mid-October in preparation for vacation.

Stupid me got on an airplane end of Oct and promptly got Covid. I was mildly sick for two weeks and had secondary symptoms (shortness of breath, vertigo, diarrhea) for another two.


Professional_Memist OP t1_j00f5yi wrote

> Abstract

> Objective:

>To evaluate dynamics of antibody levels following exposure to SARS-CoV-2 during 12 months in Dutch non-vaccinated hairdressers and hospitality staff. > > Methods:

>In this prospective cohort study, blood samples were collected every three months for one year, and analyzed using a qualitative total antibody ELISA and a quantitative IgG antibody ELISA. Participants filled out questionnaires, providing information on demographics, health and work. Differences in antibody levels were evaluated using Mann-Whitney U and Wilcoxon Signed Rank tests. Beta coefficients (B) and 95% confidence intervals (95%CI) were calculated using linear regression. > > Results:

>Ninety-five of 497 participants (19.1%) had ≥1 seropositive measurement before their last visit using the qualitative ELISA. Only 2.1% (2/95) seroreverted during follow-up. Of the 95 participants, 82 (86.3%) tested IgG seropositive in the quantitative ELISA too. IgG antibody levels significantly decreased in the first months (p<0.01), but remained detectable up to 12 months in all participants. Higher age (B, 10-years increment: 24.6, 95%CI: 5.7-43.5) and higher BMI (B, 5kg/m² increment: 40.0, 95%CI: 2.9-77.2) were significantly associated with a higher peak of antibody levels. > > Conclusions:

>In this cohort, SARS-CoV-2 antibodies persisted for up to one year after initial seropositivity, suggesting long-term natural immunity.


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yung-hoon t1_j0148o2 wrote

But we had our 3 shots