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LouieMumford t1_j05536k wrote

Reply to comment by Jealous-Pop-8997 in Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination by Razariousnefarian

This makes no sense. They would be at a low risk relative to Covid exposure. But the point is risk post exposure vs post vaccine. The study shows that risk is worse post Covid exposure vs vaccine exposure. Given the ubiquity of Covid exposure at this point one would have to do a risk analysis and would inevitably find that the vaccine is objectively safer than unvaccinated exposure to the virus. Your comment makes no sense.

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primal_screame t1_j05733h wrote

Is there any data that shows myocarditis risk after Covid exposure if you have already been vaccinated? If there is, then it would make sense there would be an additive effect of myocarditis cases from the vaccine plus myocarditis cases from catching Covid after being vaccinated. Either way, the numbers are pretty small on all the scenarios, I was just curious if there was data for that combination.

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Explorer456 t1_j05aits wrote

I think that assessing the occurrence of myocarditis in individuals who are vaccinated post COVID infection is important future research, if none is present. The possibility of there being an additive effect would likely be determined by the cause of myocarditis post infection/vaccination.

“It is under debate whether myocarditis in COVID-19 is primarily caused by the viral infection or whether it occurs secondary as a consequence of the host´s immune response, in particular by T-lymphocyte-mediated cytotoxicity or as a consequence of the cytokine storm observed during COVID-19 [25]”

The authors note that the cause of myocarditis from COVID-19 infection is up for debate. If it is related to “T-lymphocyte-mediated cytotoxicity” I am inclined to believe that there wouldn’t be an additive effect of vaccine + infection. My logic, albeit with minimal knowledge in virology, is that by have t cells created by the vaccine would be present prior to the virus. Thus able to respond prior to extensive cell infection and reduce the “T-lymphocyte-mediated cytotoxicity.”

Again, my logic my be flawed due to a misunderstanding or missing knowledge. I am open to corrections/reading to help guide me.

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primal_screame t1_j05bqi5 wrote

That makes total sense if that is the mechanism. I was trying to think if the mechanism is the same, why wouldn’t it be equal between vaccine and infection. If there was data on the combination, it might give better clarity on if it’s the same mechanism.

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Jealous-Pop-8997 t1_j056dur wrote

You are definitely confused but it does make sense. Yes, the comparison being made is myocarditis risk between Covid-19 exposure and vaccination. These risks are weighed or averaged for the general population.

Many individuals are at such a low risk of a severe covid case that they are more likely to get myocarditis resulting from vaccination

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JaelPendragon t1_j0774zc wrote

And yet you provide no proof of your baseless claim. Go get educated on the subject before spreading antivax propaganda and misinformation

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