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1

internetday t1_j1anw30 wrote

One had 5month longer effect than the other and that's it? Compared to what?

−67

medfreak t1_j1apofg wrote

Replying to internetday (#1,014,110)

https://www.annallergy.org/article/S1081-1206(22)01829-4/fulltext

By contrast, in the late time interval, IgG levels after the booster mRNA vaccine were approximately 3-fold higher (GM, 29.1 µg/mL [95% CI, 24.3-34.9]) compared with the primary series vaccination (GM, 9.5 µg/mL [95% CI, 8.1-11.1]) (P < .001) (Fig 2A). We then confirmed that there was a difference in trajectories between the booster and primary series by evaluating subjects who had paired early and late samples available. Linear regression indicated a slower IgG decay after the booster compared with the primary series vaccination, with respective slopes of −0.0024 (95% CI, −0.0037 to −0.0012) vs −0.0074 (95% CI, −0.0083 to −0.0065) (P < .001) (Fig 2B).

35

medfreak t1_j1aprpv wrote

Replying to _Chicken_Hunter (#1,014,116)

https://www.annallergy.org/article/S1081-1206(22)01829-4/fulltext

Results

There were 228 subjects who had samples collected between 7 and 150 days after their primary series vaccine and 117 subjects who had samples collected in the same time frame after their boost. Antibody levels from 7 to 31 days after the primary series and booster were similar, but S-RBD IgG was more durable over time after the boost, regardless of prior infection status. In addition, mRNA-1273 post-boost antibody levels exceeded BNT162b2 out to 5 months.

Conclusion

The COVID-19 mRNA vaccine boosters increase antibody durability, suggesting enhanced long-term clinical protection from SARS-CoV-2 infection compared with the 2-shot regimen.

43

PoshDiggory t1_j1bbjl2 wrote

I mean, yeah, that's how boosters work.

123

Denimcurtain t1_j1bbovn wrote

Replying to [deleted] (#1,013,647)

I really would appreciate a source or link to specific metrics. When I look, I see stats about how more vaccinated individuals are getting sick in aggregate than unvaccinated, people with boosters more likely to catch over time when compared to right after a booster, and even people with boosters are more likely to get Covid than they were after getting the booster relative to unvaccinated and unboosted people. That last one could throw people for a loop if they don't realize that it is just a smaller gap representing waning efficacy of the vaccines over time again.

None of those line up with what you said very authoritatively. I'd hope you were careful than you about making such a strong claim without caveats if you used raw data. If you didn't do the legwork to account for demographics and confounding variables then you run the risk of effectively being misinformation.

Flatly stating that you're more likely to get Covid when boosted is a huge claim without getting into your implication that the effect is pernicious enough to cast doubt on increased durability of antibody response.

11

-xXpurplypunkXx- t1_j1bjgqd wrote

Do we know to what extent antibody durability accounts for patient outcomes, compared with shades of immunological memory, for various strains of SARS-CoV-2? It's a shame such important work hasn't been widely and thoroughy conducted (as far as I can see from the outside googling in), but hope to understand better in the future.

14

IAMA_Plumber-AMA t1_j1brv29 wrote

Great, one of the antivax subs are brigading again. Turn back, for there's nothing of interest below this comment.

67

mwallace0569 t1_j1bxld2 wrote

Replying to Spaceman-Spiff (#1,017,595)

it sucks that sometimes people needs fear in order to get them to do something for the greater good.

i would have gotten it this month if i didn't got covid in late nov, so now i'm waiting another 3-4 months

2

derlich t1_j1ca21i wrote

Only accepted by those who didn't believe an orange hat was God's wisdom.

−22

Fallinghope7 t1_j1ca9pm wrote

“Booster shots” the Battlepass of medicine.

−25

sharmascream t1_j1ci4yo wrote

So this sub just deletes comments with a contrary opinion. Very scientific.

−29

degustibus t1_j1ck0dm wrote

Replying to Fleckeri (#1,019,423)

Totally free? Really? A novel biologic therapeutic researched, tested and manufactured in state of the art inspected clean pharmaceutical facilities-- and that's all free? Sounds like the opposite of free and you should realize that "there is no such thing as a free lunch" and just because you don't pay up front doesn't mean it's free.

It's a government paid program. Government commissioned. Government mandated in some situations. The entire need for the "Operation Warpspeed" may well stem from parts of the uS government that decided to do gain of function research and partner with the people at the Wuhan Institute for VIrology.

What's another big way it's not free? Well some people do indeed have adverse events and some include death. As for the data on this, providers have been pressured and instructed not to record this in many places and now news of corruption of data making genuine research impossible. GIGO

−22

ThingCalledLight t1_j1ck8bi wrote

Replying to sharmascream (#1,019,664)

I know. There was a post about diamond being the world’s hardest mineral and when I—a total nobody with zero scientific expertise and without any tested evidence—commented that I thought the hardest mineral was bubblegum, they shot me down too.

“Science.” Pshaw, I say!

33

Websting t1_j1d8u77 wrote

It’s weird how the deniers are still going strong. At this point don’t we all know someone that was affected by Covid? We are a few years in now and I don’t know a single person that has had a problem with the vaccine besides a sore arm. However, I know several that died from Covid, and it was gruesome. Luckily those days seem to be behind us, but how do the deniers think we got here? Did the virus just magically disappear in well vaccinated countries?

14

bobbi21 t1_j1dhlhz wrote

Replying to Websting (#1,021,556)

In their heads, anyone who died of covid was misdiagnosed and died of something else... and anyone who died of anything else they say died of the vaccine. Its an easy lie to continue if you already assume the entire healthcare community is lying to you.

8

Websting t1_j1din30 wrote

Replying to bobbi21 (#1,022,489)

So starting with a fever and cough that leads to respiratory failure and ventilators followed by kidney failure, cardiac arrest, and stroke in the course of a couple of weeks is just normal. Sounds perfectly fine to me.

5

Fastgirl600 t1_j1dnc44 wrote

When will there be a need for a second bivalent booster?

1

danielravennest t1_j1f2dpn wrote

Replying to Fastgirl600 (#1,023,143)

Based on what I have seen in study results, 6 months or whenever a new variant becomes dominant and a specific booster for it becomes available. Unfortunately COVID is rapidly mutating, and nobody seems to have developed a long-term vaccine yet.

I'm OK with that schedule. I'm used to getting a flu vaccine every fall, with a similar situation of different variants in circulation each year.

3