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Wagamaga OP t1_j686i5n wrote

COVID vaccines and first boosters provided significant protection to pregnant women against severe complications and death, even after the arrival of the new Omicron variant, according to a study published this week in The Lancet medical journal.

This study "demonstrates a vaccine effectiveness in preventing severe complications of severe COVID-19 of 76% following vaccination and at least one booster," said Dr. Michael Gravett, an OB-GYN with the University of Washington School of Medicine who participated in the study, which was led by Oxford University. "Given the marked increased in maternal mortality and severe morbidity seen in our earlier studies prior to vaccination, the 76% efficacy is pretty impressive and really points to the need to get women vaccinated."

The main point of the study, which was completed before other variants came on the scene, is for pregnant women to get vaccinated and receive all their boosters, including the bivalent booster, he said.The bivalent booster contains components targeting the original strain of the virus as well as a component of the Omicron strain, which emerged in late 2021.

As of the first week of January, 71% of pregnant women have received their primary COVID vaccines but only 19% have received the recommended bivalent booster, according the the U.S.Centers for Disease Control and Prevention (CDC). In Washington state, only 29% of pregnant women have received the bivalent booster, Gravett said.

Gravett noted that the study, one of the largest of its kind, compared outcomes of 1,545 pregnant women diagnosed with COVID-19 with those of 3,073 pregnant women without the infection. UW Medicine sites were one of three in the United States included in the study. Gravett and Dr. Alisa Kachikis guided the Seattle part of the study, which included around 75 women from UW Medical Center-Montlake, UW Medical Center-Northwest and Harborview Medical Center.


slo1111 t1_j689ygu wrote

Nice study.

A good visual

Vaccinated and with covid.
-108 had no symptoms -206 had any type symptoms

Not Vaccinated and with covid

  • 57 had no symptoms
  • 88 had symptoms

That is a rather drastic difference and supports the end premise.

The only thing that could be warranted to further scrutinize is gaging whether the covid test type could introduce enough possible false positives to change the end results. Maybe it is addressed but I missed it. If I recall 20% of the tests were the quick test.


so2017 t1_j69q0s9 wrote

Based on the time frame of the study it looks like this describes the impact of standard boosters, not bivalent boosters, correct?


shiruken t1_j69s6bd wrote

Correct, participants were enrolled from November 27, 2021 to June 30, 2022. The bivalent booster was not authorized until August 31, 2022.

That being said, vaccination was still highly effective at preventing several maternal complications and outcomes:

>Reassuringly, the vaccine effectiveness of all vaccines combined to prevent severe maternal morbidity and referral, ICU admission, or death was 76% amongst all women given a booster dose. The respective vaccine effectiveness values for mRNA vaccines with a booster dose was 81%. For women with a diagnosis, vaccine effectiveness for the same outcomes, of all vaccines combined, was 74% (95% CI 48–87) for the complete regimen and 91% (65–98) after a booster dose.


techinvestor t1_j6azc2l wrote

What's the relative risk of covid deaths in this population?


Dr_D-R-E t1_j6b82ex wrote

Obgyn MD checking in

Without getting into the weeds of which vaccine does what for which variant

COVID infection during pregnancy has been ASSOCIATED with about a 40% incidence of hypertensive disorders in pregnancy, such as preeclampsia

Fallout from this is less well studied but that can increase incidence of preterm delivery (which has its own issues) increased need for induction of labor at 37 weeks rather than showing natural labor to occur and increased risk for c section


slo1111 t1_j6oujdm wrote

I can see my ability to gage ratios is suspect. Thanks for the correction.

It does make me wonder if the quick covid test type could alter the results although it appears false positives are not a big issue with the tests as false negatives are.