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Brasscogs t1_j5v8l5p wrote

Reply to comment by VaporLockBox in Canadian scientists exposed mice to vapour from JUUL e-cigarettes and found it caused changes in the animals' pulmonary immune cell composition and altered gene and protein levels in their lungs. by MistWeaver80

Yeah they said the system was supposed to simulate 3 years worth of vaping for a human but I find that comparison highly dubious. High dose short-term can’t be directly converted to short dose long-term I believe. I don’t work with mice however so correct me if I’m wrong.

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VaporLockBox t1_j5ve7v2 wrote

The roughly 3 years equivalency came from dividing the length of the treatment period by the median lifespan of the mice. 4 weeks / 25 months. So 0.04 x median lifespan of a human (rounding to 80 years) = 3.2 years.

For the sake of argument let’s agree that 4 weeks = 3 years is a good enough mouse-equivalency to define a chronic (long-term) span of time.

The other factors should also have been adjusted to mouse-equivalencies to avoid conducting a study with no relevance to human activity. Especially factors related to lung size and function.

Otherwise all that the study could study was extreme high-dosing and/or hypoxia in mice. With absolutely no application to even extremist human use patterns over any time frame.

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