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FailOsprey t1_j5yj597 wrote

... propylene glycol, vegetable glycerin, and nicotine are the only three required ingredients, all of which have decades of research that can be used to generalize their risk upon the lungs.

Also, the vast majority of flavors are FDA approved and many of them have had extensive research done on them, especially those that are used in cooking, frying, etc. There are unknowns, but that doesn't mean we can't quantify the long-term risks. Some of the earliest research accurately predicting the danger of tobacco, for example, were the result of relatively brief experiments on animals in the lab.

Don't get me wrong, there are unknowns. At least some unscrupulous vendors are adding novel ingredients to their e-juice, and some of those are bound to have risks. If the FDA was as worried with consumer protection as they are in handing the industry to the tobacco companies, I'd have been able to provide a better answer than I did.