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Hanflander t1_j479zqs wrote

5HT2A receptor agonism from classical psychedelics is also associated with increased BDNF (brain-derived neurotrophic factor), which leads to neurogenesis and more connections between brain cells. This is even evident after a single administration. Look up “psychoplastogens.”


Possumsurprise t1_j47f95g wrote

Is this observed with purely monomeric-targeting 5HT2AR agonists though? Because the psychedelics exert their strong perceptual effects and I believe some other effects by binding to those in an oligomer with mGluR2,to disinhibit glutamate activity, though I think there had been challenges to that idea recently. Either way there would be something more to the effects of psychedelics at 5HT2ARs because those like lisuride that bind to the monomeric form only don’t induce the same kind of effects, though I may be missing something.


Rodot t1_j47cda2 wrote

It should be noted that amphetamine also increases BDNF and improves functional connectivity in the brain while promoting neurogensis, while also causing less confusion.