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ifitfartsitsharts t1_j5ddrej wrote

I am a physician and would NOT recommend anyone with bipolar take shrooms. The risk of an adverse event is too high in people with psychiatric illness with psychotic features including bipolar disorder. Also, many people with bipolar/depression are on psychiatric meds and there isn’t much data on risks of things like serotonin sydrome and other complications like prolonged psychosis, precipitating a manic episode, etc. That being said, we need more objective data (with VALIDATED measures). I recently presented a Grand Rounds lecture on Psilocybin, its mechanisms, and current applications.

Edit: some highlights from the study design and results

  • Subjects were recruited via online advertisements on the CREST.BD website and social media.

  • “self-reported bipolar disorder diagnosis”

Sample bias and very likely including misdiagnoses and people with something not actually bipolar (personality disorder, mild schizophrenia, depression, thyroid disorder). There are a lot of people with “bipolar” self-diagnosed. And there are a lot of people who are older that have bipolar diagnoses that are not truly bipolar but were misdiagnosed in the past.

  • “On a five-point scale from “Not at all” to “Extremely harmful,” the participants rated the harmfulness of their psilocybin experience “.

Having a wide range of time from last use can affect the results. Recency/time bias, inaccurate recall of events and symptoms the further out they get. Also, not a validated measure.

  • “The most commonly cited reason for using psilocybin was to aid personal development, followed by to have fun.”

That’s cool, but I think that says something about the population under study. Patient recruitment methods likely influenced this.

  • “32.2% of participants reported experiencing negative or unwanted outcomes during or in the 14 days after a psilocybin trip. New or increasing manic symptoms were the most common side effect. Eighteen people reported the use of emergency services during or in the 14 days after a psilocybin trip.”

Well that doesn’t sound great.

  • “While our study shows that some people with bipolar disorder reported positive experiences of psilocybin use, others experienced significant bad outcomes, so using this substance can be risky.”

I don’t like this study and think it’s bad because of flawed methodology. But if it helps to get a clinical trial (which they say is underway), then I guess this weak and biased survey data is helpful. I expect that they would use validated symptom severity scales such as the Young Mania Rating Scale (YMRS) or Bech-Rafaelsen Mania Rating Scale (MAS) for future and ongoing clinical research.

For more info on bipolar diagnosis and symptom monitoring for those who are interested: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847794/

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iicyysaberr t1_j5djv0t wrote

Finally, A educated comment. I also wanted to say people treating mental issues with Marijuana can be very bad too depending on the person.

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ifitfartsitsharts t1_j5dksl7 wrote

Agree. Evidence is lacking for cannabis in most of what people say it is helpful for. If people find it helpful, that’s great! It’s still an exogenous psychoactive compound with its own set of risks.

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iicyysaberr t1_j5dkzux wrote

Agreed, And we can do more testing if the government would federally legalize it but until then we can't fully test it. But for people saying it's a miracle plant and has not problems is absolute nonsense.

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pineapplepredator t1_j5fj8d9 wrote

I never knew this but knew a guy who had some paranoia and delusion in his reasoning generally and he started smoking weed every day to help with his tantrums. It helped his moods while he was high but overall, his delusions and paranoia became way worse so that when he wasn’t high, he was acting psychotic more often than not. It was scary. If someone you know is having issues with their reasoning, keep them away from weed

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RiChessReadit t1_j5dr9f5 wrote

If I smoke regularly for more than a week or two it can move my usual mild depression into suicidal territory. I also get really severe weeks long insomnia whenever I stop using it.

Finally had to swear off it completely.

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New_Revenue_4_U t1_j5ev91j wrote

Agree. Have bipolar and smoked weed for over 15 year's. Never again.

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iicyysaberr t1_j5f6j8m wrote

What happened when you smoked

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roberto1 t1_j5fdzla wrote

The reason he is bipolar probably because of the weed..

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New_Revenue_4_U t1_j5frjsn wrote

i actually don't know if it is drug induced but tbh i wouldn't discount the possibility.

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JonWinstonCarl t1_j5dxefp wrote

I feel like this study is very disconnected from its subject/audience. I have no medical background whatsoever, but Ive done a decent amount of mushrooms, and I would NEVER recommend them to somebody who exhibits manic behavior or uncontrollable thoughts. Just from an anectdotal standpoint, they amplify anything you are feeling so dramatically that I think if you had a downturn while tripping it would be a disaster. I absolutely love mushrooms, but I've recommended against my wife and friends doing them because they have depression issues and dont have a real medical expert to supervise them.

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azorielios t1_j5g6dwj wrote

I am bipolar, and before being diagnosed I did a substantial quantity of shrooms. You’re right - it was intense. It was also incredibly cathartic, and for weeks afterward each time I was calmer and more stable.

I also recognize that the plural of ancedote isn’t data, so maybe I just seriously lucked out.

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lizardlines t1_j5fu1el wrote

That was my experience taking psilocybin as part of a study on BD2. Amplified my obsessive negative thoughts and was a miserable experience. I’d try psilocybin again but never while severely depressed.

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f4f4f4f4f4f4f4f4 t1_j5drj31 wrote

Thank you, Dr. ifitfartsitsharts! I thought that was funny, but really, thank you for looking into this, and warning people to not mix medications. Bipolar is scary and unpredictable enough as it is, ruining the data will make treating the condition even more difficult.

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teatimewithbatman1 t1_j5dl10q wrote

Being on meds may be a problem given the pharmaceutical changes of biochemistry.....but we still don't really know what bipolar is. The most we've got is a chemical imbalance that fluctuates during the day, and paired with psychotherapy, different aspects of each day correlating with mental thought processes that push the chemical body into different responses.

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lizardlines t1_j5ftfge wrote

I was part of a clinical trial for psilocybin use for BD2 where I was given psilocybin under observation. I was severely depressed at the time and the experience itself was miserable, just amplifying obsessive thoughts. In the long term it didn’t hurt but I personally would not do it again when severely depressed. But the PI said many participants had good results.

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Captain_Peelz t1_j5h7h44 wrote

In your opinion, do you believe that people conflate the short term high and associated happiness with a perceived long term positive effect? Because I know several people who swear that it has helped them, yet they show no signs of improved happiness or stability. They just do drugs more frequently.

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ifitfartsitsharts t1_j5hoqzg wrote

Yes, I think there is a component of that, which is why studies need proper design for the question and validated measurement tools that eliminate that kind of bias.

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ayleidanthropologist t1_j5fzj48 wrote

Thanks for your input on this. I know it takes time to do write ups like these. But it is appreciated!

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drakens6 t1_j5gkdic wrote

The critical thing to note about usage of serotonergics or dopaminergics when recommending their use for treatment is that people's baseline levels of those neurotransmitters, their receptor sensitivity, and theirability to convert/process precursors metabolically into active substances can vary wildly depending on a number of different pathological and developmental factors. Just as with anti-depressants, marijuana and psilocybin can be radically detrimental to individuals with specific conditions, and its use can result in real harm to those people

No medicine is beneficial every time, at every dose, to every person. Everything has it's drawbacks and diagnosis considerations, and safer administration protocols with proper harm reduction controls do exist and can be utilized, even in a non-clinical setting.

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n3w4cc01_1nt t1_j5gmlrn wrote

If it were a professional treatment do you think keeping a fast acting sleep medication on hand could avoid this?

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palsh7 t1_j5gngjw wrote

I was thinking, “people with bipolar disorder don’t always know what is real, let alone helpful.”

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ClassyRedandGlassy t1_j5i35ev wrote

Nurse here and thank you for clarifying things to the general audience because I don’t think regular people should be experimenting with their mental health and psychedelics based on Reddit. I fear more self diagnosed people are trying to DIY their mental health these days and it’s having negative effects on their outlook overall. People are using these studies to justify its use but blindly going about doing so in an uncontrolled setting and I don’t support that. Regardless, I know right off the bat that a bipolar diagnosed person has tendencies to abuse substances, how is this any different? Will they not have more potential to become obsessive with the hallucinogenic properties? Seems like a mixed bag

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omeyz t1_j5pvj2v wrote

Thank you, this is like bipolar 101. Psychedelics could sooo easily be a catalyst for a severe manic episode

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Thegarbagegamer97 t1_j5c5wft wrote

For a disorder that can have all sorts of effects on behavior and mental state, an online format self reporting method seems sketchy. I know you have to start somewhere but i think the jury is gonna have to be out a little longer on this one

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rxneutrino t1_j5c7d60 wrote

>For their study, the researchers used a blog post on the CREST.BD website and social media advertisements to recruit a sample of 541 individuals who were at least 18 years old, had a self-reported bipolar disorder diagnosis, and had used psilocybin to achieve “a full psychedelic trip.”

>On a five-point scale from “Not at all” to “Extremely harmful,” the participants rated the harmfulness of their psilocybin experience as 1.6 on average. In contrast, they rated the perceived helpfulness of their psilocybin experience as 4 on average.

>However, 32.2% of participants reported experiencing negative or unwanted outcomes during or in the 14 days after a psilocybin trip. New or increasing manic symptoms were the most common side effect. Eighteen people reported the use of emergency services during or in the 14 days after a psilocybin trip.

So on average, participants thought it was more helpful than harmful, but 1 in 3 had worsening symptoms? Definitely needs more scrutiny.

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Earthboom t1_j5c8ea0 wrote

I was definitely the 1 in 3 and it sucks. Felt great for about a week after the trip and then I became suicidal on week 2. Took myself into care and got the proper medication.

Shrooms have potential but there's quite a lot of work needed to rule out the kinks.

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Thegarbagegamer97 t1_j5c7v35 wrote

Defining helpful with a disorder like that is what im curious about. HOW does it improve it? Does it deal with the mania? The depression? Just a general improvement? So many questions to be had and so little info given.

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Kaylycat t1_j5dddjk wrote

Diagnosed bipolar since I was 8, I took a few shrooms w my ex and it literally lifted the fog of depression, the world wasn't so bleary and eh and I didn't SEE it that way either. Normally life doesnt seem so worth living, and i feel genuinely happy? Normal? I can only say that it did make me feel amazing, I had no side effects after coming off of it and i even had another dose a couple weeks later, felt the same exact way. I can DEFINITELY see this being a natural medicine if taken maybe once a week? And in moderation w a doctor helping you. It seems, by tthe study, that some people experienced the side effects of technically cold turkeying a medication, no different than ssris but maybe something that could be managed with a doctors watch.

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Holycrapwtfatheism t1_j5ewtbq wrote

Anecdotal and not bipolar but recently fell into a bit of a depressive funk. Tried 2g shrooms for the first time and it was like a brain reset. My mood calmed, the depressed feelings just left. Hopefully more legitimate studies can shed more light onto psilocybin and therapeutic uses.

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Thegarbagegamer97 t1_j5ddtz4 wrote

Only asking this out of curiosity, but when you say it made you feel amazing, are we talking the healthy and stable kind or the euphoric kind that mania can sometimes induce? The article talked about that being a possible adverse effect so would love the input

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turntabletennis t1_j5fhfxh wrote

The euphoria from mushrooms is far greater than I have ever experienced during any mania. It's not an "on top of the world" feeling, it's more of a physical body euphoria with absolute clarity of mind.

I find myself able to think unabated by my own opinions or spin. You are able to rationalize with yourself. Sometimes this rationality CAN lead to intense feelings of sadness, as you accept responsibility for your past actions, or accept flaws within yourself.

I am fairly sure that watching It's Always Sunny in Philadelphia while tripping on shrooms contributed heavily to me quitting drinking alcohol. The reason being that I recognized my own drunk behavior in their jokes. Like damn, I'm the joke. Then my brain rearranged. It's hard to explain, but you truly do THINK a different way with psilocybin.

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DrEpileptic t1_j5d7rfl wrote

Also, how does the tolerance work with it?

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OfLittleToNoValue t1_j5db628 wrote

Mushroom tolerance builds and wanes quickly.

Most people will feel something around 1g. 3gs is a solid trip.

Onset can be an hour or so and the effects can last about 6 hours.

Micro dosing is about .1g every 3-4 days. Using even such a small amount daily can still build tolerance that renders them far less effective.

There's growing research into everything from depression and autism and PTSD and more being helped by psilocybin.

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Fluid_Negotiation_76 t1_j5d3mjh wrote

Dosage is an important factor. I took way more than most people take and had a constructive trip. Looking back, that kind of risk seeking behavior and disregard for potential danger is a hallmark of a manic episode. I would recommend anyone with bipolar to avoid unnecessary risks, including drugs.

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Specialist_Carrot_48 t1_j5fgnc3 wrote

Self selection bias is also massive on this. Those who had a good experience are more likely to respond

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roberto1 t1_j5fd6r8 wrote

You know what feels great when your bipolar. Being manic! Do you know why induces manic behavior in people with underlying conditions. Psychedelics do! You are correct in that these people should not be self reporting. The data will not be accurate. As someone with bipolar I can describe some of my best times and have people around me explain why they were my worst...

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harmonyofthespheres t1_j5dessb wrote

100% this.

After doing mushrooms several times I completely believe they have the potential to help many ailments/disorders, but honestly bipolar is not one that I would have guessed. In fact, I wouldn't be surprised if they made bipolar worse. I remember reading an article that the entropic brain theory of psychedelics developed by robin Carhart Harris hinted that it could potentially be bad for bipolar.

I also have a bipolar sibling who is getting their life together right now and my gut tells me mushrooms would be too risky for them. I would definitely wait for the science on this one.

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KittenKoder t1_j5dfr4b wrote

I am personally getting tired of the self reporting "studies" being touted as representative of entire populations. This bad science is getting out of hand, especially regarding woo like natural drugs.

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420caveman t1_j5d25wi wrote

No offense to anybody with this condition but my best mate whose bipolar had some mushrooms and NOPE. I DO NOT THINK PEOPLE WITH THIS CONDITION SHOULD HAVE THIS DRUG.

Especially when they're already taking prescription medicine from the doctor for it.

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AirNeal t1_j5d4l10 wrote

Yeah just hired a maid who swears microdosing cured her bipolar. Doesn't seem very cured from my observations.

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420caveman t1_j5d65hp wrote

Yeah, they think all the drugs they take on top of the doctors treatment is helping them.

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DrEpileptic t1_j5d7z0m wrote

There’s a famous twitch streamer that killed himself a few years back when the microdosing wasn’t helping him anymore. Dude was taking an ungodly amount of shrooms every day because he’d built up such a tolerance.

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[deleted] t1_j5dt1ah wrote

[deleted]

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amutualravishment t1_j5dufta wrote

Some people can eliminate the disorder from their life so thoroughly they no longer have any symptoms. I know it's not something that psychiatrists are known to do, but if someone fails to meet the criteria for a dsm diagnosis, the doctor would have to conclude they no longer have the disorder.

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jrodshibuya t1_j5d5lbf wrote

I have bipolar and was very firmly warned off all hallucinogenic substances. Also is self-reporting reliable? The individuals believing it is helpful isn’t the same as objective analysis.

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MadScience_Gaming t1_j5dnp2t wrote

Bipolar person here. Wouldn't be surprised if those more motivated to self-report were more likely to be on the upswing than the down.

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Takuukuitti t1_j5f0mbq wrote

No, it isnt reliable. People with bipolar should avoid all drugs. The point psych meds is to stabilize mood. Shrooms do the exact opposite and definitely can trigger a manic episode.

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themysterioustoaster t1_j5dbc69 wrote

I don’t think the fact that psilocybin can induce mania should shut down exploring its potential to treat BD. Even medications FDA approved for BD can induce mania. It’d be nice to compare the frequency of induced mania between psilocybin vs mood stabilizers/antipsychotics.

Edit: no I’m not just referencing the infamous antidepressants

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Hi_Her t1_j5eraag wrote

Right. Many antidepressants are known to cause mania in bipolar patients and they get prescribed them all the time.

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Takuukuitti t1_j5f0tyf wrote

Antipsychotics dont induce manias, but some other mood stabilizers and SSRIs can. That is why they require follow up and are commonly used only with antipsychotics, not in isolation (and should be stopped if hypomania symptoms occur).

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themysterioustoaster t1_j5g2whv wrote

Antipsychotics have induced hypo/mania. I know this because of my experience on Abilify. I ended up taking it a 2nd time, was in a rough spot and my thought process was like “well atleast I know what to expect from this one” haha… and had a similar experience the 2nd time! Hypo/mania is considered a rare side effect. I don’t think there is enough data to say how often this happens with patients. There’s even a risk of psychosis with some of these meds. A very small risk, to be fair.

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Elessar535 t1_j5guyli wrote

As someone who is bipolar and is prescribed meds by a psychiatrist, I can attest to this. My lithium keeps me from having serious lows, but the caveat is that it can also push me into a manic episode, so I am also on asenapine (an antipsychotic) to control my mania. Basically my brain chemistry is a constant match of tug of war between two prescribed chemicals. It usually works out ok and keeps me in a slightly more balanced mental state, but it can also go terribly wrong and throw me to one or the other extreme; I also no longer remember what it feels like to be clear headed, or to have any real control over my mood/emotions (I can't help but feel like waking up every morning is a complete roll of the dice). So it goes.

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thewoodschild t1_j5er9mj wrote

I have bipolar it's not fun. But I've never had issues with psychedelics. I do prefer mushrooms though. I've had a lot of personal break throughs and doing a large dose holds me over well for about two months. I know some of the worries with people who are mentally ill using psychedelics but nothing else works like this does. I've tried a ton of meds and none of em do much for me. I'd rather eat a natural mushroom every few months than to swallow a few pills everyday. I'm glad they are finally digging into the benefits of it.

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cerpintaxt33 t1_j5di7yd wrote

Bipolar 1 here. This is anecdotal, but I began microdosing last April for 6 weeks and I almost immediately starting feeling better. I began exercising, lost weight and found a new job. I plan to try it again next time I have a downswing.

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ObamaLovesKetamine t1_j5e9vgo wrote

I think Psilocybin can be a fantastic catalyst to help people get out of depressive spirals; i think where most people who self-medicate with them go wrong is thinking of it as "the cure" and start abusing the substance in an effort to keep the absurd at bay.

It can be good to break a spiral and help one to find the momentum to establish healthier behaviors and coping mechanisms, but that takes more effort than a lot of people who already struggle with depression and the likes are prepared to put in. Genuine sweeping life changes are hard to establish, and even harder to maintain.

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easylemon828 t1_j5g9xok wrote

This happened for me too. I know it’s anecdotal but for me I see a real change in the way my brain thinks. Way more stability and rational thought which is way different from my depressive swings. I’m actually able to overcome my negative thought patterns and inner criticism. But something tells me deep down that “tripping” or macrodosing would NOT be positive for me personally. Micro dosing seems to be where I reap the benefits. But I have the same relationship with weed. Small amounts of thc and cbd really relax me, but anymore than that is anxiety/panic attack inducing. But I will also say I’m NOT on any medication. I know pharmaceutical meds and psychedelics do not mix well so I cannot say my experience with both.

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WaxyWingie t1_j5d42h2 wrote

Self reporting is a horrible way to measure something like this.

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Present_Use_6357 t1_j5ccu8n wrote

Marijuana triggered the worst mixed episode of my life but I didn’t notice anything with shrooms.

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iicyysaberr t1_j5djy55 wrote

Can you explain? I too had a horrible experience.

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Present_Use_6357 t1_j5dndrq wrote

I took an edible and went catatonic and hallucinated for hours. For the next month or so I had racing thoughts that were so bad I would stare off into space for hours before coming back to reality. The content of my racing thoughts were very paranoid and full of rage. It was like being the most angry you can possibly be, non stop for weeks. When I would come too I would cry because I wanted it to stop so bad but within seconds I would be back in the thought spiral. I also had all the other classic mixed symptoms (depression/fatigue mixed with no sleep, agitation, rapid speaking, and a lot of energy). It culminated with more intense delusions, thinking I was in a simulation and other people were robots ect. I gradually stabilized with antipsychotics but have since weened off of them. Unfortunately, the racing thoughts, rage and paranoia have comeback but to a lesser degree and I am afraid that it’s my new baseline.

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Exoddity t1_j5dp8bg wrote

type 2 here. When I'm on mushrooms, I'm relaxed. Everything I do is more focused, more deliberate, and with greater ease. I'm more creative, I'm more sociable, and generally at my best with regard to everything I do. The world around me seems more vibrant, less depressing, and you would not ever think for a second that I'm "on" something, other than noting how at ease I am compared to normal, if you know me.

The only problem is it's not the kind of drug you can just take all the time. I relegate myself to once every couple months, in order to get the most from the experience. I've been growing my own for the last 13 years or so and have never had a single bad experience with them. But I also have a rule against sharing psychoactive / hallucinogenics with other people because you never know how they're going to react. It's definitely not something I'd recommend to some one who isn't somewhat grounded as a person. If you're given to notions of the supernatural, without understanding (to the best you can, currently) the science behind what's going on with your brain when you take them, I think you're going to have a bad time.

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ClioEclipsed t1_j5cqebx wrote

"Scientists unravel the mysteries of the cosmos" as shown by this online self-reported survey.

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Neat_Art9336 t1_j5dfzy9 wrote

You are absolutely not supposed to consume things that alter your mental state when you have bipolar disorder. That’s bipolar 101. I have it, all doctors have said this.

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PurpedSavage t1_j5ds6bm wrote

According to people that smoke cigs it apparently relieves stress

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YoWhatItDoMyDude t1_j5e03nb wrote

I am bipolar type 2 and used psychedelics for a large period of time and the only thing I found was with extended periods of use I had an extended period of depression.

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healthierlurker t1_j5d0l3k wrote

It was for me. But there was just a post on the one bipolar sub about someone who had an awful experience.

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Steveb523 t1_j5e6spd wrote

Helpful, or at least damned fun.

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Chronotaru t1_j5f0kf7 wrote

What's I'd most like to know is how the mania with those who had problems progressed over a longer period, say a couple of months. If the psilocybin helped eliminate or reduce the depression aspects, the mania went no mania for a week, increase in mania for another week or two, then balance back to what it was before the experience while the depression is still either gone or better then I would count that as a win. Meanwhile if the mania is still heightened after two months then that might be hard to justify even if the depression aspects were reduced.

The full holistic picture is rarely possible to obtain from any of these studies with the focus on quantitative data.

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ifitfartsitsharts t1_j5g9d5z wrote

Problem is, when people have a manic episode, their judgment is severely compromised and they can ruin their lives in days (gambling, risky behaviors, medical effects). Some people will spend all of their money during an episode and ruin themselves financially. So even if the absolute risk of having a manic episode is low, the consequences of having one can be catastrophic. Theres no insurance for unintentionally ruining your life (non-medically) while having a manic episode.

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Chronotaru t1_j5gai9l wrote

People who have bipolar one already have manic episodes. A very temporary increase isn’t adding anything new, it’s making their lives more difficult for a while in which they might mean they need more support in that window. In a hypothetical scenario it might even be worthwhile to be an inpatient for a week to ride it out of there was a payoff.

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jeswaldo t1_j5cecn3 wrote

"Rewire" the brain a little with some Scooby snacks.

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CalligrapherPitiful3 t1_j5dlby2 wrote

What we believe is helpful is not the same thing as helpful. As an addict I used to believe using was helping me cope with negative feelings. I was wrong. This is the most ridiculously absurd claim I've read all day. I'm all for the possibility of hallucinogens having medical value, but this is nothing but click bait.

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btw5062 t1_j5dul43 wrote

I have depressive bipolar disorder and shrooms did help a little bit for the first 2-3 trips. After that I started having seizures mid trip so I don’t do that anymore obv. Wouldn’t recommend.

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sweetgoogilymoogily t1_j5dw6lk wrote

Until you get serotonin sickness from taking them while on medication. Helpful will be the least of your worries!

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[deleted] t1_j5e3fdu wrote

As a bipolar sufferer I’ve learned the hard ways MOST medications that impact mental faculties have Wiley varying effects on us. Please be wary anyone else with this issue thinking this is a free pass to try this

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GayTaco_ t1_j5ea209 wrote

puzzelers are beginning to make jigsaw puzzle, believe it may be some kittens in a basket.

Please don't take shrooms if you are suffering from BPD based on just this paper.

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New_Revenue_4_U t1_j5eun9d wrote

Still won't get me trying them. Heard too many bad stories of mushroom trips.

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team_pupNsuds95 t1_j5fxuiy wrote

It’s like a fresh snowfall after every time I’ve tripped. All the gouges and cuts I’ve overthought into my daily think box are wiped clean. I’m more content and able to focus for WEEKS after just one session.

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ludolek t1_j5fy44g wrote

Let me tell you from 15y experience as a psychiatric nurse in a acute psychiatric ward.

Bipolar people think a lot of stuff is helpful that isnt…

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ludolek t1_j5fybq3 wrote

Let me tell you from 15y experience as a psychiatric nurse in a acute psychiatric ward.

Bipolar people think a lot of stuff is helpful that isnt…

Not to talk down psilocybin or anything… just saying

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hotpepperrelish t1_j5gm8lw wrote

I read another headline today (no, I did not read the article) saying that our gut microbiome has effects on lots of other physiological aspects. Out of curiosity, does anyone know if there's been research into why psilocybin has positive effects on a variety of mental conditions? Is it therapeutic in the psychological sense, or perhaps it effects our gut biome which improves long term mental state?

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Exotic_Crazy3503 t1_j5gnn6g wrote

I’m bipolar an found after 35 years that ketamine is the only med that has helped me

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cloudjianrider t1_j5i8887 wrote

I’ve taken lots of psilocybin and lots of lithium and I can say without a doubt the lithium works better. Not as fun as the psilocybin though.

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Conundrum1859 t1_j5ds0qe wrote

Interesting note, working on an electronics device that can induce states similar to DSL but fully reversible and much safer. Uses a novel brain scanning technique I invented.

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mrmeowmeowington t1_j5fhqb5 wrote

I’ve attended a few psilocybin conferences and they say the same, if you’re diagnosed bipolar or with schizophrenia, it is dangerous to do while in that manic state. You have to be very careful.

There are professionals in some states like California and colorido where you can speak to them about being prescribed psilocybin and if you’re a candidate.

Please be safe.

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windythought34 t1_j5dwp6m wrote

The headline says that drug addicts say drugs are helpful? Or did I get this wrong?

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