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themysterioustoaster t1_j5dbc69 wrote

I don’t think the fact that psilocybin can induce mania should shut down exploring its potential to treat BD. Even medications FDA approved for BD can induce mania. It’d be nice to compare the frequency of induced mania between psilocybin vs mood stabilizers/antipsychotics.

Edit: no I’m not just referencing the infamous antidepressants

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Hi_Her t1_j5eraag wrote

Right. Many antidepressants are known to cause mania in bipolar patients and they get prescribed them all the time.

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Takuukuitti t1_j5f0tyf wrote

Antipsychotics dont induce manias, but some other mood stabilizers and SSRIs can. That is why they require follow up and are commonly used only with antipsychotics, not in isolation (and should be stopped if hypomania symptoms occur).

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themysterioustoaster t1_j5g2whv wrote

Antipsychotics have induced hypo/mania. I know this because of my experience on Abilify. I ended up taking it a 2nd time, was in a rough spot and my thought process was like “well atleast I know what to expect from this one” haha… and had a similar experience the 2nd time! Hypo/mania is considered a rare side effect. I don’t think there is enough data to say how often this happens with patients. There’s even a risk of psychosis with some of these meds. A very small risk, to be fair.

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Elessar535 t1_j5guyli wrote

As someone who is bipolar and is prescribed meds by a psychiatrist, I can attest to this. My lithium keeps me from having serious lows, but the caveat is that it can also push me into a manic episode, so I am also on asenapine (an antipsychotic) to control my mania. Basically my brain chemistry is a constant match of tug of war between two prescribed chemicals. It usually works out ok and keeps me in a slightly more balanced mental state, but it can also go terribly wrong and throw me to one or the other extreme; I also no longer remember what it feels like to be clear headed, or to have any real control over my mood/emotions (I can't help but feel like waking up every morning is a complete roll of the dice). So it goes.

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