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phriot t1_iw2gytu wrote

Reply to comment by draem in Shape of a protein predicted by two different AI models (ESMFold on the left, AlphaFold on the right) by greentea387

It's probably a membrane protein, which would make it difficult to crystalize to get a structure experimentally. That's the promise of software like AlphaFold.

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MyCoffeeTableIsShit t1_iw4iwiq wrote

I would like to introduce you to the world of mesophase crystallisation, good sir.

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iyke7991 t1_iw6g0cs wrote

Advantages?

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MyCoffeeTableIsShit t1_iw6pu0e wrote

It provides an artificial lipid matrix which stabilises multiple domains simultaneously making some membrane proteins more amenable to crystallisation.

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iyke7991 t1_iw8j66b wrote

Ahhh, will need to look into it more. Some cutting edge stuff right there. Biology is way too complex. Endless forever evolving complexity. Absolutely beautiful. Make it stop. 😭😭😂

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