Shape of a protein predicted by two different AI models (ESMFold on the left, AlphaFold on the right)vhu9644 t1_iwau2w1 wrote
Reply to comment by wazabee in Shape of a protein predicted by two different AI models (ESMFold on the left, AlphaFold on the right) by greentea387
And I’m a synthetic biologist in protein engineering. What I’m skeptical about is that for this protein specifically, this change in structure plays a major role in function determination, due to its simplicity, and that we are seeing two distinct folds that are locked from each other.
The point ultimately is moot, the protein chosen is a membrane bound protein, so the lipid layer will provide stabilization.
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