Yes. These designs are basically highly optimized, non-uniform load structures. You validate their load capability the same way you validate complex parts designed by humans: finite element analysis (FEA).

Edit: FEA is how you validate before your first prototype is made. You also CNC or 3D print a prototype and physically stress it just like any other part. Design validation is NOT just done on paper. It also is done on prototypes made using non-production equipment / tooling.